Internal Atom Exchange in Oxazole Rings: A Blueprint for Azole Scaffold 
Evaluation

Spinnato, Davide; Leutzsch, Markus; Wang, Feng; Cornella, Josep

doi:10.1055/a-2201-9285

アイテム詳細

登録内容を編集ファイル形式で保存

一時保存へ追加

タグ情報を表示リリース履歴を表示詳細要約

公開

学術論文

Internal Atom Exchange in Oxazole Rings: A Blueprint for Azole Scaffold Evaluation

MPS-Authors

/persons/resource/persons280838

Spinnato, Davide
Research Group Cornellà, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

/persons/resource/persons132873

Leutzsch, Markus
Service Department Farès (NMR), Max-Planck-Institut für Kohlenforschung, Max Planck Society;

/persons/resource/persons231581

Wang, Feng
Research Group Cornellà, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

/persons/resource/persons207433

Cornella, Josep
Research Group Cornellà, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

External Resource

There are no locators available

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

フルテキスト (公開)

公開されているフルテキストはありません

付随資料 (公開)

There is no public supplementary material available

引用

Spinnato, D., Leutzsch, M., Wang, F., & Cornella, J. (2024). Internal Atom Exchange in Oxazole Rings: A Blueprint for Azole Scaffold Evaluation. Synlett, 35(9), 1015-1018. doi:10.1055/a-2201-9285.

引用: https://hdl.handle.net/21.11116/0000-000D-E37A-A

要旨

In this article we provide a route to transform isoxazoles and oxadiazoles into the corresponding pyrazoles and 1,2,4-triazoles in 1-step using catalytic amounts of an air-stable Ni(0) complex. The reaction is a formal atom exchange process at the internal heteroatoms of the aromatic cycle. This work provides a blueprint for reactivity that permits the rapid evaluation of different 5-membered azole scaffolds, thus avoiding de novo synthesis of the molecule of interest.