Primary cilia are WNT-transducing organelles whose biogenesis is controlled by 
a WNT-PP1 axis.

Zhang, Kaiqing; Silva, Fabio Da; Seidl, Carina; Wilsch-Bräuninger, Michaela; Herbst, Jessica; Huttner, Wieland; Niehrs, Christof

doi:10.1016/j.devcel.2022.12.006

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Primary cilia are WNT-transducing organelles whose biogenesis is controlled by a WNT-PP1 axis.

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Wilsch-Bräuninger, Michaela
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Huttner, Wieland
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Citation

Zhang, K., Silva, F. D., Seidl, C., Wilsch-Bräuninger, M., Herbst, J., Huttner, W., et al. (2023). Primary cilia are WNT-transducing organelles whose biogenesis is controlled by a WNT-PP1 axis. Developmental cell, 58(2), 139-154. doi:10.1016/j.devcel.2022.12.006.

Cite as: https://hdl.handle.net/21.11116/0000-000E-AB38-3

Abstract

WNT signaling is important in development, stem cell maintenance, and disease. WNT ligands typically signal via receptor activation across the plasma membrane to induce β-catenin-dependent gene activation. Here, we show that in mammalian primary cilia, WNT receptors relay a WNT/GSK3 signal that β-catenin-independently promotes ciliogenesis. Characterization of a LRP6 ciliary targeting sequence and monitoring of acute WNT co-receptor activation (phospho-LRP6) support this conclusion. Ciliary WNT signaling inhibits protein phosphatase 1 (PP1) activity, a negative regulator of ciliogenesis, by preventing GSK3-mediated phosphorylation of the PP1 regulatory inhibitor subunit PPP1R2. Concordantly, deficiency of WNT/GSK3 signaling by depletion of cyclin Y and cyclin-Y-like protein 1 induces primary cilia defects in mouse embryonic neuronal precursors, kidney proximal tubules, and adult mice preadipocytes.