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Journal Article

Response to Comment on "Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals".

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Pinson,  Anneline
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons219252

Huttner,  Wieland
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Citation

Pinson, A., Maricic, T., Zeberg, H., Pääbo, S., & Huttner, W. (2023). Response to Comment on "Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals". Science (New York, N.Y.), 379(6636), 2212-2212. doi:10.1126/science.adf2212.


Cite as: https://hdl.handle.net/21.11116/0000-000E-AB40-9
Abstract
Herai et al. discuss the known fact that a low percentage of modern humans who lack any overt phenotypes carry the ancestral TKTL1 allele. Our paper demonstrates that the amino acid substitution in TKTL1 increases neural progenitor cells and neurogenesis in the developing brain. It is another question if, and to what extent, this has consequences for the adult brain.