A clinical screening tool to detect genetic cancer predisposition in pediatric 
oncology shows high sensitivity but can miss a substantial percentage of 
affected children.

Friedrich, Ulrike; Bienias, Marc; Zinke, Claudia; Prazenicova, Maria; Lohse, Judith; Jahn, Arne; Menzel, Maria; Langanke, Jonas; Walter, Carolin; Wagener, Rabea; Brozou, Triantafyllia; Varghese, Julian; Dugas, Martin; Erlacher, Miriam; Schröck, Evelin; Suttorp, Meinolf; Borkhardt, Arndt; Hauer, Julia; Auer, Franziska

doi:10.1016/j.gim.2023.100875

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A clinical screening tool to detect genetic cancer predisposition in pediatric oncology shows high sensitivity but can miss a substantial percentage of affected children.

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Schröck, Evelin
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Citation

Friedrich, U., Bienias, M., Zinke, C., Prazenicova, M., Lohse, J., Jahn, A., et al. (2023). A clinical screening tool to detect genetic cancer predisposition in pediatric oncology shows high sensitivity but can miss a substantial percentage of affected children. Genetics in medicine: official journal of the American College of Medical Genetics, 25(8): 100875. doi:10.1016/j.gim.2023.100875.

Cite as: https://hdl.handle.net/21.11116/0000-000F-0619-F

Abstract

Clinical checklists are the standard of care to determine whether a child with cancer shows indications for genetic testing. Nevertheless, the efficacy of these tests to reliably detect genetic cancer predisposition in children with cancer is still insufficiently investigated.