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Customized enhancement of thermal sensitivity of tumors at different subcutaneous depths by multichannel lanthanide nanocomposites

MPG-Autoren
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Liu,  Yuxin       
Felix Löffler, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Löffler,  Felix F.
Felix Löffler, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Zitation

Liu, Y., Wei, Z., Zhang, J., Xu, Y., Zhou, J., Ma, Z., et al. (2024). Customized enhancement of thermal sensitivity of tumors at different subcutaneous depths by multichannel lanthanide nanocomposites. Advanced Materials, 2402981. doi:10.1002/adma.202402981.


Zitierlink: https://hdl.handle.net/21.11116/0000-000F-1402-8
Zusammenfassung
The photothermal therapeutic effect on tumors located at different subcutaneous depths varies due to the attenuation of light by tissue. Here, based on the wavelength-dependent optical attenuation properties of tissues, the tumor depth was assessed using a multichannel lanthanide nanocomposite. A metal-organic framework ZIF-8-coated nanocomposite was able to deliver high amounts of the hydrophilic heat shock protein 90 inhibitor epigallocatechin gallate through a hydrogen-bonding network formed by the encapsulated highly polarized polyoxometalate guest. It was superior to both bare and PEGylated ZIF-8 for drug delivery. With the assessment of tumor depth and accumulated amount of nanocomposite by fluorescence, an irradiation prescription can be customized to release sufficient HSP90 inhibitor and generate heat for sensitized photothermal treatment of tumors, which not only ensured therapeutic efficacy but also minimized damage to the surrounding tissues.