日本語
 
Help Privacy Policy ポリシー/免責事項
  詳細検索ブラウズ

アイテム詳細


公開

学術論文

Origin and dispersal history of Hepatitis B virus in Eastern Eurasia

MPS-Authors
/persons/resource/persons203211

Andrades Valtueña,  Aida       
Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

/persons/resource/persons247389

Kocher,  Arthur       
Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

/persons/resource/persons72801

Krause,  Johannes       
Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

/persons/resource/persons179620

Herbig,  Alexander       
Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

External Resource
There are no locators available
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
フルテキスト (公開)

Sun_Origin_NatComm_2024.pdf
(出版社版), 10MB

付随資料 (公開)

Sun_Origin_NatComm_Suppl_2024.pdf
(付録資料), 41MB

引用

Sun, B., Andrades Valtueña, A., Kocher, A., Gao, S., Li, C., Fu, S., Zhang, F., Ma, P., Yang, X., Qiu, Y., Zhang, Q., Ma, J., Chen, S., Xiao, X., Damchaabadgar, S., Li, F., Kovalev, A., Hu, C., Chen, X., Wang, L., Li, W., Zhou, Y., Zhu, H., Krause, J., Herbig, A., & Cui, Y. (2024). Origin and dispersal history of Hepatitis B virus in Eastern Eurasia. Nature Communications, 15:. doi:10.1038/s41467-024-47358-6.


引用: https://hdl.handle.net/21.11116/0000-000F-291D-4
要旨
Hepatitis B virus is a globally distributed pathogen and the history of HBV infection in humans predates 10000 years. However, long-term evolutionary history of HBV in Eastern Eurasia remains elusive. We present 34 ancient HBV genomes dating between approximately 5000 to 400 years ago sourced from 17 sites across Eastern Eurasia. Ten sequences have full coverage, and only two sequences have less than 50% coverage. Our results suggest a potential origin of genotypes B and D in Eastern Asia. We observed a higher level of HBV diversity within Eastern Eurasia compared to Western Eurasia between 5000 and 3000 years ago, characterized by the presence of five different genotypes (A, B, C, D, WENBA), underscoring the significance of human migrations and interactions in the spread of HBV. Our results suggest the possibility of a transition from non-recombinant subgenotypes (B1, B5) to recombinant subgenotypes (B2 - B4). This suggests a shift in epidemiological dynamics within Eastern Eurasia over time. Here, our study elucidates the regional origins of prevalent genotypes and shifts in viral subgenotypes over centuries.