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  The Obese Taste Bud study: Objectives and study design

Kersten, A., Lorenz, A., Nottmeier, C., Schmidt, M., Roesner, A., Richter, F. C., et al. (2024). The Obese Taste Bud study: Objectives and study design. Diabetes, Obesity and Metabolism, 26(6), 2054-2068. doi:10.1111/dom.15563.

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 Urheber:
Kersten, Alexander1, Autor
Lorenz, Andrea2, Autor
Nottmeier, Cita3, Autor
Schmidt, Michael4, Autor
Roesner, Anuschka5, Autor
Richter, Florian Christoph6, Autor
Röhrborn, Kristin7, Autor
Witte, A. Veronica8, 9, Autor                 
Hahnel, Sebastian2, 4, Autor
Koehne, Till3, Autor
Blüher, Matthias1, 7, Autor
Stumvoll, Michael1, 7, Autor
Rohde‐Zimmermann, Kerstin7, Autor
Schamarek, Imke1, 7, Autor
Affiliations:
1Department of Endocrinology, Nephrology, Rheumatology, University of Leipzig, Germany, ou_persistent22              
2Department of Prosthodontics and Materials Science, University of Leipzig, Germany, ou_persistent22              
3Department of Orthodontics, University Hospital Leipzig, Germany, ou_persistent22              
4Clinic of Prosthodontics, University Hospital Regensburg, Germany, ou_persistent22              
5Department of Prosthetic Dentistry, University Medical Center, Freiburg, Germany, ou_persistent22              
6Department of Anaesthesiology and Intensive Care, University Hospital Leipzig, Germany, ou_persistent22              
7Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Leipzig, Germany, ou_persistent22              
8Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
9Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

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Schlagwörter: Aims: Taste modifies eating behaviour, impacting body weight and potentially obesity development. The Obese Taste Bud (OTB) Study is a prospective cohort study launched in 2020 at the University of Leipzig Obesity Centre in cooperation with the HI-MAG Institute. OTB will test the hypothesis that taste cell homeostasis and taste perception are linked to obesity. Here, we provide the study design, data collection process and baseline characteristics. Materials and methods: Participants presenting overweight, obesity or normal weight undergo taste and smell tests, anthropometric, and taste bud density (TBD) assessment on Day 1. Information on physical and mental health, eating behaviour, physical activity, and dental hygiene are obtained, while biomaterial (saliva, tongue swap, blood) is collected in the fasted state. Further blood samples are taken during a glucose tolerance test. A stool sample is collected at home prior to Day 2, on which a taste bud biopsy follows dental examination. A subsample undergoes functional magnetic resonance imaging while exposed to eating-related cognitive tasks. Follow-up investigations after conventional weight loss interventions and bariatric surgery will be included. Results: Initial results show that glycated haemoglobin levels and age are negatively associated with TBD, while an unfavourable metabolic profile, current dieting, and vegan diet are related to taste perception. Olfactory function negatively correlates with age and high-density lipoprotein cholesterol. Conclusion: Initial findings suggest that metabolic alterations are relevant for taste and smell function and TBD. By combining omics data from collected biomaterial with physiological, metabolic and psychological data related to taste perception and eating behaviour, the OTB study aims to strengthen our understanding of taste perception in obesity.
 Zusammenfassung: Inflammation; Metabolic disease; Obesity; Oral microbiome; Taste cell homeostasis; Taste perception

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Sprache(n): eng - English
 Datum: 2024-03-012023-12-152024-03-042024-04-152024-06
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.1111/dom.15563
Anderer: epub 2024
PMID: 38618969
 Art des Abschluß: -

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Projektname : -
Grant ID : -
Förderprogramm : Junior research grant
Förderorganisation : Medical Faculty, University of Leipzig
Projektname : -
Grant ID : 2021_EKEA.30
Förderprogramm : -
Förderorganisation : Else Kröner-Fresenius-Foundation

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Titel: Diabetes, Obesity and Metabolism
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Oxford : Wiley
Seiten: - Band / Heft: 26 (6) Artikelnummer: - Start- / Endseite: 2054 - 2068 Identifikator: ISSN: 1463-1326
CoNE: https://pure.mpg.de/cone/journals/resource/1463-1326