Non-invasive high-resolution in vivo pH mapping in brain tumors by 31P‑informed 
deepCEST MRI

Schüre, J-R; Rajpu, J; Steidl, E; Shrestha, M; Deichmann, R; Hattingen, E; Fabian, M; Maier, A; Nagel, A; Zaiss, M

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Non-invasive high-resolution in vivo pH mapping in brain tumors by 31P‑informed deepCEST MRI

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Zaiss, M
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Schüre, J.-R., Rajpu, J., Steidl, E., Shrestha, M., Deichmann, R., Hattingen, E., Fabian, M., Maier, A., Nagel, A., & Zaiss, M. (2024). Non-invasive high-resolution in vivo pH mapping in brain tumors by 31P‑informed deepCEST MRI. Poster presented at ISMRM & ISMRT Annual Meeting & Exhibition 2024, Singapore.

引用: https://hdl.handle.net/21.11116/0000-000F-39B8-2

要旨

Motivation: The pH value is an important biomarker for many diseases. MRI-based 3D pH mapping for clinical routine would be an enormous benefit for diagnostics. Goal(s): Prediction of intracellular P-pH maps from H APTw-CEST MRI data using a voxel-wise neural network, aiming to improve brain tumor imaging. Approach: Fifteen glioblastoma patients underwent 3T MRI with both APTw-CEST and P-MRS. A neural network trained on 11 patients data to correlate APTw-CEST features with P-derived pH values, tested on 4 additional patients. Results: The neural network's pH predictions closely matched P-pH maps, showing potential for high-resolution, non-invasive pH mapping in brain tumors. Impact: High resolution pH imaging for better diagnosis of diseases (inflammation, stroke, tumor) and therapy monitoring in clinical routine.