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  Genetic variants for head size share genes and pathways with cancer

Knol, M. J., Poot, R. A., Evans, T. E., Satizabal, C. L., Mishra, A., Sargurupremraj, M., et al. (2024). Genetic variants for head size share genes and pathways with cancer. Cell Reports Medicine, 101529. doi:10.1016/j.xcrm.2024.101529.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000F-43AD-3 Version Permalink: https://hdl.handle.net/21.11116/0000-000F-43AE-2
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 Creators:
Knol, Maria J.1, Author
Poot, Raymond A.1, Author
Evans, Tavia E.1, Author
Satizabal, Claudia L.1, Author
Mishra, Aniket1, Author
Sargurupremraj, Muralidharan1, Author
van der Auwera, Sandra1, Author
Duperron, Marie-Gabrielle1, Author
Jian, Xueqiu1, Author
Hostettler, Isabel C.1, Author
van Dam-Nolen, Dianne H.K.1, Author
Lamballais, Sander1, Author
Pawlak, Mikolaj A.1, Author
Lewis, Cora E.1, Author
Carrion-Castillo, Amaia1, Author
van Erp, Theo G.M.1, Author
Reinbold, Céline S.1, Author
Shin, Jean1, Author
Scholz, Markus1, Author
Håberg, Asta K.1, Author
Kämpe, Anders1, AuthorLi, Gloria H.Y.1, AuthorAvinun, Reut1, AuthorAtkins, Joshua R.1, AuthorHsu, Fang-Chi1, AuthorAmod, Alyssa R.1, AuthorLam, Max1, AuthorTsuchida, Ami1, AuthorTeunissen, Mariël W.A.1, AuthorAygün, Nil1, AuthorPatel, Yash1, AuthorLiang, Dan1, AuthorBeiser, Alexa S.1, AuthorBeyer, Frauke2, Author                 Bis, Joshua C.1, AuthorBos, Daniel1, AuthorBryan, R. Nick1, AuthorBülow, Robin1, AuthorCaspers, Svenja1, AuthorCatheline, Gwenaëlle1, AuthorCecil, Charlotte A.M.1, AuthorDalvie, Shareefa1, AuthorDartigues, Jean-François1, AuthorDeCarli, Charles1, AuthorEnlund-Cerullo, Maria1, AuthorFord, Judith M.1, AuthorFranke, Barbara1, AuthorFreedman, Barry I.1, AuthorFriedrich, Nele1, AuthorGreen, Melissa J.1, AuthorHaworth, Simon1, AuthorHelmer, Catherine1, AuthorHoffmann, Per1, AuthorHomuth, Georg1, AuthorIkram, M. Kamran1, AuthorJack, Clifford R.1, AuthorJahanshad, Neda1, AuthorJockwitz, Christiane1, AuthorKamatani, Yoichiro1, AuthorKnodt, Annchen R.1, AuthorLi, Shuo1, AuthorLim, Keane1, AuthorLongstreth, W.T.1, AuthorMacciardi, Fabio1, AuthorAmouyel, Philippe1, AuthorArfanakis, Konstantinos1, AuthorAribisala, Benjamin S.1, AuthorBastin, Mark E.1, AuthorChauhan, Ganesh1, AuthorChen, Christopher1, AuthorCheng, Ching-Yu1, Authorde Jager, Philip L.1, AuthorDeary, Ian J.1, AuthorFleischman, Debra A.1, AuthorGottesman, Rebecca F.1, AuthorGudnason, Vilmundur1, AuthorHilal, Saima1, AuthorHofer, Edith1, AuthorJanowitz, Deborah1, AuthorJukema, J. Wouter1, AuthorLiewald, David C.M.1, AuthorLopez, Lorna M.1, AuthorLopez, Oscar1, AuthorLuciano, Michelle1, AuthorMartinez, Oliver1, AuthorNiessen, Wiro J.1, AuthorNyquist, Paul1, AuthorRotter, Jerome I.1, AuthorRundek, Tatjana1, AuthorSacco, Ralph L.1, AuthorSchmidt, Helena1, AuthorTiemeier, Henning1, AuthorTrompet, Stella1, Authorvan der Grond, Jeroen1, AuthorVölzke, Henry1, AuthorWardlaw, Joanna M.1, AuthorYanek, Lisa1, AuthorYang, Jingyun1, AuthorAgartz, Ingrid1, AuthorAlhusaini, Saud1, AuthorAlmasy, Laura1, AuthorAmes, David1, AuthorAmunts, Katrin1, AuthorAndreassen, Ole A.1, AuthorArmstrong, Nicola1, AuthorBernard, Manon1, AuthorBlangero, John1, AuthorBlanken, Laura M.E.1, AuthorBoks, Marco P.1, AuthorBoomsma, Dorret I.1, AuthorBrickman, Adam M.1, AuthorBrodaty, Henry1, AuthorBuckner, Randy L.1, AuthorBuitelaar, Jan K.1, AuthorCannon, Dara M.1, AuthorCarr, Vaughan J.1, AuthorCatts, Stanley V.1, AuthorChakravarty, M. Mallar1, AuthorChen, Qiang1, AuthorChing, Christopher R.K.1, AuthorCorvin, Aiden1, AuthorCrespo-Facorro, Benedicto1, AuthorCurran, Joanne E.1, AuthorDavies, Gareth E.1, Authorde Geus, Eco J.C.1, Authorde Zubicaray, Greig I.1, Authorden Braber, Anouk1, AuthorDesrivières, Sylvane1, AuthorDillman, Allissa1, AuthorDjurovic, Srdjan1, AuthorDrevets, Wayne C.1, AuthorDuggirala, Ravi1, AuthorEhrlich, Stefan1, AuthorErk, Susanne1, AuthorEspeseth, Thomas1, AuthorFedko, Iryna O.1, AuthorFernández, Guillén1, AuthorFisher, Simon E.1, AuthorForoud, Tatiana M.1, AuthorGe, Tian1, AuthorGiddaluru, Sudheer1, AuthorGlahn, David C.1, AuthorGoldman, Aaron L.1, AuthorGreen, Robert C.1, AuthorGreven, Corina U.1, AuthorGrimm, Oliver1, AuthorHansell, Narelle K.1, AuthorHartman, Catharina A.1, AuthorHashimoto, Ryota1, AuthorHeinz, Andreas1, AuthorHenskens, Frans1, AuthorHibar, Derrek P.1, AuthorHo, Beng-Choon1, AuthorHoekstra, Pieter J.1, AuthorHolmes, Avram J.1, AuthorHoogman, Martine1, AuthorHottenga, Jouke-Jan1, AuthorHulshoff Pol, Hilleke E.1, AuthorJablensky, Assen1, AuthorJenkinson, Mark1, AuthorJia, Tianye1, AuthorJöckel, Karl-Heinz1, AuthorJönsson, Erik G.1, AuthorKim, Sungeun1, AuthorKlein, Marieke1, AuthorKochunov, Peter1, AuthorKwok, John B.1, AuthorLawrie, Stephen M.1, AuthorLe Hellard, Stephanie1, AuthorLemaître, Hervé1, AuthorLoughland, Carmel1, AuthorMarquand, Andre F.1, AuthorMartin, Nicholas G.1, AuthorMartinot, Jean-Luc1, AuthorMatarin, Mar1, AuthorMathalon, Daniel H.1, AuthorMather, Karen A.1, AuthorMattay, Venkata S.1, AuthorMcDonald, Colm1, AuthorMcMahon, Francis J.1, AuthorMcMahon, Katie L.1, AuthorE, Rebekah1, AuthorMcWhirter1, AuthorMecocci, Patrizia1, AuthorMelle, Ingrid1, AuthorMeyer-Lindenberg, Andreas1, AuthorMichie, Patricia T.1, AuthorMilaneschi, Yuri1, AuthorMorris, Derek W.1, AuthorMowry, Bryan1, AuthorNho, Kwangsik1, AuthorNichols, Thomas E.1, AuthorNöthen, Markus N.1, AuthorOlvera, Rene L.1, AuthorOosterlaan, Jaap1, AuthorOphoff, Roel A.1, AuthorPandolfo, Massimo1, AuthorPantelis, Christos1, AuthorPappa, Irene1, AuthorPenninx, Brenda1, AuthorPike, G. Bruce1, AuthorRasser, Paul E.1, AuthorRentería, Miguel E.1, AuthorReppermund, Simone1, AuthorRietschel, Marcella1, AuthorRisacher, Shannon L.1, AuthorRomanczuk-Seiferth, Nina1, AuthorRose, Emma Jane1, AuthorSachdev, Perminder S.1, AuthorSämann, Philipp G.1, AuthorSaykin, Andrew J.1, AuthorSchall, Ulrich1, AuthorSchofield, Peter R.1, AuthorSchramm, Sara1, AuthorSchumann, Gunter1, AuthorScott, Rodney1, AuthorShen, Li1, AuthorSisodiya, Sanjay M.1, AuthorSoininen, Hilkka1, AuthorSprooten, Emma1, AuthorSrikanth, Velandai1, AuthorSteen, Vidar M.1, AuthorStrike, Lachlan T.1, AuthorThalamuthu, Anbupalam1, AuthorToga, Arthur W.1, AuthorTooney, Paul1, AuthorTordesillas-Gutiérrez, Diana1, AuthorTurner, Jessica A.1, AuthorValdés Hernández, Maria del C.1, Authorvan der Meer, Dennis1, AuthorVan der Wee, Nic J.A.1, AuthorVan Haren, Neeltje E.M.1, Authorvan 't Ent, Dennis1, AuthorVeltman, Dick J.1, AuthorWalter, Henrik1, AuthorWeinberger, Daniel R.1, AuthorWeiner, Michael W.1, AuthorWen, Wei1, AuthorWestlye, Lars T.1, AuthorWestman, Eric1, AuthorWinkler, Anderson M.1, AuthorWoldehawariat, Girma1, AuthorWright, Margaret J.1, AuthorWu, Jingqin1, AuthorMäkitie, Outi1, AuthorMazoyer, Bernard1, AuthorMedland, Sarah E.1, AuthorMiyamoto, Susumu1, AuthorMoebus, Susanne1, AuthorMosley, Thomas H.1, AuthorMuetzel, Ryan1, AuthorMühleisen, Thomas W.1, AuthorNagata, Manabu1, AuthorNakahara, Soichiro1, AuthorPalmer, Nicholette D.1, AuthorPausova, Zdenka1, AuthorPreda, Adrian1, AuthorQuidé, Yann1, AuthorReay, William R.1, AuthorRoshchupkin, Gennady V.1, AuthorSchmidt, Reinhold1, AuthorSchreiner, Pamela J.1, AuthorSetoh, Kazuya1, AuthorShapland, Chin Yang1, AuthorSidney, Stephen1, AuthorSt Pourcain, Beate1, AuthorStein, Jason L.1, AuthorTabara, Yasuharu1, AuthorTeumer, Alexander1, AuthorUhlmann, Anne1, Authorvan der Lugt, Aad1, AuthorVernooij, Meike W.1, AuthorWerring, David J.1, AuthorWindham, B. Gwen1, AuthorWitte, A. Veronica2, Author                 Wittfeld, Katharina1, AuthorYang, Qiong1, AuthorYoshida, Kazumichi1, AuthorBrunner, Han G.1, AuthorLe Grand, Quentin1, AuthorSim, Kang1, AuthorStein, Dan J.1, AuthorBowden, Donald W.1, AuthorCairns, Murray J.1, AuthorHariri, Ahmad R.1, AuthorCheung, Ching-Lung1, AuthorAndersson, Sture1, AuthorVillringer, Arno2, Author                 Paus, Tomas1, AuthorCichon, Sven1, AuthorCalhoun, Vince D.1, AuthorCrivello, Fabrice1, AuthorLauner, Lenore J.1, AuthorWhite, Tonya1, AuthorKoudstaal, Peter J.1, AuthorHoulden, Henry1, AuthorFornage, Myriam1, AuthorMatsuda, Fumihiko1, AuthorGrabe, Hans J.1, AuthorIkram, M. Arfan1, AuthorDebette, Stéphanie1, AuthorThompson, Paul M.1, AuthorSeshadri, Sudha1, AuthorAdams, Hieab H.H.1, Author more..
Affiliations:
1External Organizations, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

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Free keywords: Genetics; Genome-wide association study; Head size; Intracranial volume; Head circumference; Cancer; Meta-analysis
 Abstract: The size of the human head is highly heritable, but genetic drivers of its variation within the general population remain unmapped. We perform a genome-wide association study on head size (N = 80,890) and identify 67 genetic loci, of which 50 are novel. Neuroimaging studies show that 17 variants affect specific brain areas, but most have widespread effects. Gene set enrichment is observed for various cancers and the p53, Wnt, and ErbB signaling pathways. Genes harboring lead variants are enriched for macrocephaly syndrome genes (37-fold) and high-fidelity cancer genes (9-fold), which is not seen for human height variants. Head size variants are also near genes preferentially expressed in intermediate progenitor cells, neural cells linked to evolutionary brain expansion. Our results indicate that genes regulating early brain and cranial growth incline to neoplasia later in life, irrespective of height. This warrants investigation of clinical implications of the link between head size and cancer.

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Language(s): eng - English
 Dates: 2023-09-182021-11-302024-04-042024-05-03
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.xcrm.2024.101529
Other: online ahead of print
PMID: 38703765
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Grant ID : P30AG066546
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Funding organization : South Texas Alzheimer’s Disease Research Center
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Title: Cell Reports Medicine
  Abbreviation : CELL REP MED
Source Genre: Journal
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Publ. Info: RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS : Elsevier
Pages: - Volume / Issue: - Sequence Number: 101529 Start / End Page: - Identifier: CoNE: https://pure.mpg.de/cone/journals/resource/2666-3791