A taste of a toxin paradise: Xenorhabdus and Photorhabdus bacterial secondary 
metabolites against Aedes aegypti larvae and eggs

Ulug, Derya; Touray, Mustapha; Hazal Gulsen, Sebnem; Cimen, Harun; Hazir, Canan; Bode, Helge B.; Hazir, Selcuk

doi:10.1016/j.jip.2024.108126

アイテム詳細

登録内容を編集ファイル形式で保存

一時保存へ追加

タグ情報を表示リリース履歴を表示詳細要約

公開

学術論文

A taste of a toxin paradise: Xenorhabdus and Photorhabdus bacterial secondary metabolites against Aedes aegypti larvae and eggs

MPS-Authors

/persons/resource/persons256033

Bode, Helge B.
Natural Product Function and Engineering, Department of Natural Products in Organismic Interactions, Max Planck Institute for Terrestrial Microbiology, Max Planck Society;

External Resource

https://doi.org/10.1016/j.jip.2024.108126
(出版社版)

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

フルテキスト (公開)

公開されているフルテキストはありません

付随資料 (公開)

There is no public supplementary material available

引用

Ulug, D., Touray, M., Hazal Gulsen, S., Cimen, H., Hazir, C., Bode, H. B., & Hazir, S. (2024). A taste of a toxin paradise: Xenorhabdus and Photorhabdus bacterial secondary metabolites against Aedes aegypti larvae and eggs. Journal of Invertebrate Pathology, 205:. doi:10.1016/j.jip.2024.108126.

引用: https://hdl.handle.net/21.11116/0000-000F-4508-B

要旨

Aedes-transmitted arboviral infections such as Dengue, Yellow Fever, Zika and Chikungunya are increasing public health problems. Xenorhabdus and Photorhabdus bacteria are promising sources of effective compounds with important biological activities. This study investigated the effects of cell-free supernatants of X. szentirmaii, X. cabanillasii and P. kayaii against Ae. aegypti eggs and larvae and identified the bioactive larvicidal compound in X. szentirmaii using the easyPACId approach. Among the three tested bacterial species, X. cabanillasii exhibited the highest (96%) egg hatching inhibition and larvicidal activity (100% mortality), whereas P. kayaii was the least effective species in our study. EasyPACId method revealed that bioactive larvicidal compound in the bacterial supernatant was fabclavine. Fabclavines obtained from promoter exchange mutants of different bacterial species such as X. cabanillasii, X. budapestensis, X. indica, X. szentirmaii, X. hominckii and X. stockiae were effective against mosquito larvae. Results show that these bacterial metabolites has a potential to be used in integrated pest management (IPM) programmes of mosquitoes.