Single-value brain activity scores reflect both severity and risk across the 
Alzheimer's continuum

Soch, Joram; Richter, Anni; Kizilirmak, Jasmin M.; Schütze, Hartmut; Ziegler, Gabriel; Altenstein, Slawek; Brosseron, Frederic; Dechent, Peter; Fliessbach, Klaus; Freiesleben, Silka Dawn; Glanz, Wenzel; Gref, Daria; Heneka, Michael T.; Hetzer, Stefan; Incesoy, Enise I.; Kilimann, Ingo; Kimmich, Okka; Kleineidam, Luca; Kuhn, Elizabeth; Laske, Christoph; Lohse, Andrea; Lüsebrink, Falk; Munk, Matthias H.; Peters, Oliver; Preis, Lukas; Priller, Josef; Ramirez, Alfredo; Roeske, Sandra; Rostamzadeh, Ayda; Roy-Kluth, Nina; Scheffler, Klaus; Schmid, Matthias; Schneider, Anja; Spottke, Annika; Spruth, Eike Jakob; Teipel, Stefan; Wiltfang, Jens; Jessen, Frank; Wagner, Michael; Düzel, Emrah; Schott, Björn H.

doi:10.1093/brain/awae149

アイテム詳細

登録内容を編集ファイル形式で保存

一時保存へ追加

タグ情報を表示リリース履歴を表示詳細要約

公開

学術論文

Single-value brain activity scores reflect both severity and risk across the Alzheimer's continuum

MPS-Authors

/persons/resource/persons289663

Soch, Joram
Max Planck Research Group Learning in Early Childhood, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

External Resource

https://github.com/JoramSoch/DELCODE_SAME
(Code)

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

フルテキスト (公開)

Soch_accepted.pdf
(全文テキスト（全般）), 598KB

Soch_pre.pdf
(プレプリント), 3MB

付随資料 (公開)

Soch_2024_Suppl.pdf
(付録資料), 3MB

引用

Soch, J., Richter, A., Kizilirmak, J. M., Schütze, H., Ziegler, G., Altenstein, S., Brosseron, F., Dechent, P., Fliessbach, K., Freiesleben, S. D., Glanz, W., Gref, D., Heneka, M. T., Hetzer, S., Incesoy, E. I., Kilimann, I., Kimmich, O., Kleineidam, L., Kuhn, E., Laske, C., Lohse, A., Lüsebrink, F., Munk, M. H., Peters, O., Preis, L., Priller, J., Ramirez, A., Roeske, S., Rostamzadeh, A., Roy-Kluth, N., Scheffler, K., Schmid, M., Schneider, A., Spottke, A., Spruth, E. J., Teipel, S., Wiltfang, J., Jessen, F., Wagner, M., Düzel, E., & Schott, B. H. (2024). Single-value brain activity scores reflect both severity and risk across the Alzheimer's continuum. Brain. doi:10.1093/brain/awae149.

引用: https://hdl.handle.net/21.11116/0000-000F-540E-4

要旨

Single-value scores reflecting the deviation from (FADE score) or similarity with (SAME score) prototypical novelty-related and memory-related functional magnetic resonance imaging (fMRI) activation patterns in young adults have been proposed as imaging biomarkers of healthy neurocognitive aging. Here, we tested the utility of these scores as potential diagnostic and prognostic markers in Alzheimer’s disease (AD) and risk states like mild cognitive impairment (MCI) or subjective cognitive decline (SCD).

To this end, we analyzed subsequent memory fMRI data from individuals with SCD, MCI, and AD dementia as well as healthy controls (HC) and first-degree relatives of AD dementia patients (AD-rel) who participated in the multi-center DELCODE study (N = 468). Based on the individual participants’ whole-brain fMRI novelty and subsequent memory responses, we calculated the FADE and SAME scores and assessed their association with AD risk stage, neuropsychological test scores, CSF amyloid positivity, and ApoE genotype.

Memory-based FADE and SAME scores showed a considerably larger deviation from a reference sample of young adults in the MCI and AD dementia groups compared to HC, SCD and AD-rel. In addition, novelty-based scores significantly differed between the MCI and AD dementia groups. Across the entire sample, single-value scores correlated with neuropsychological test performance. The novelty-based SAME score further differed between Aβ-positive and Aβ-negative individuals in SCD and AD-rel, and between ApoE ε4 carriers and non-carriers in AD-rel.

Hence, FADE and SAME scores are associated with both cognitive performance and individual risk factors for AD. Their potential utility as diagnostic and prognostic biomarkers warrants further exploration, particularly in individuals with SCD and healthy relatives of AD dementia patients.