Molecular surface chemistry defines nematode development, identity and behaviour

Kotowska, Anna M.; Hiramatsu, Fumie; Alexander, Morgan R.; Scurr, David J.; Lightfoot, James W; Chauhan, Veeren M.

doi:10.1101/2024.04.24.590549

アイテム詳細

登録内容を編集ファイル形式で保存

一時保存へ追加

タグ情報を表示リリース履歴を表示詳細要約

公開

学術論文

Molecular surface chemistry defines nematode development, identity and behaviour

MPS-Authors

/persons/resource/persons290325

Hiramatsu, Fumie
Max Planck Research Group Genetics of Behavior, Max Planck Institute for Neurobiology of Behavior – caesar, Max Planck Society;
International Max Planck Research School (IMPRS) for Brain and Behavior, Max Planck Institute for Neurobiology of Behavior – caesar, Max Planck Society;

/persons/resource/persons252140

Lightfoot, James W
Max Planck Research Group Genetics of Behavior, Max Planck Institute for Neurobiology of Behavior – caesar, Max Planck Society;

External Resource

https://www.biorxiv.org/content/10.1101/2024.04.24.590549v1
(プレプリント)

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

フルテキスト (公開)

公開されているフルテキストはありません

付随資料 (公開)

There is no public supplementary material available

引用

Kotowska, A. M., Hiramatsu, F., Alexander, M. R., Scurr, D. J., Lightfoot, J. W., & Chauhan, V. M. (2024). Molecular surface chemistry defines nematode development, identity and behaviour. bioRxiv. doi:10.1101/2024.04.24.590549.

引用: https://hdl.handle.net/21.11116/0000-000F-639D-1

要旨

Chemical signalling facilitates organismal communication and coordinates physiological and behavioural processes. In nematodes, chemical signalling has focused on secreted molecules leaving the surface’s communicative potential unexplored. Utilising 3D-OrbiSIMS surface-sensitive mass spectrometry, we directly characterise the molecular surface composition of Caenorhabditis elegans and Pristionchus pacificus. Their surfaces consist of a complex, lipid-dominated landscape with distinct developmental profiles and species-specific characteristics. These surface-anchored chemistries depend on the peroxisomal fatty acid β-oxidation component daf-22 and are essential for interaction-based behaviours including predation and kin-recognition. Specific lipid molecules identified as putative kin-recognition associated surface components include diglyceride (DG O-50:13), ceramide phosphate (CerP 41:1;O3), and hexosylceramide (HexCer 40:2;O3). Thus, we reveal the nematode surface is a dynamic signalling interface, pivotal for deciphering molecular mechanisms regulating development, identity and contact-dependent behaviour.