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Journal Article

Molecular surface chemistry defines nematode development, identity and behaviour

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Hiramatsu,  Fumie       
Max Planck Research Group Genetics of Behavior, Max Planck Institute for Neurobiology of Behavior – caesar, Max Planck Society;
International Max Planck Research School (IMPRS) for Brain and Behavior, Max Planck Institute for Neurobiology of Behavior – caesar, Max Planck Society;

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Lightfoot,  James W       
Max Planck Research Group Genetics of Behavior, Max Planck Institute for Neurobiology of Behavior – caesar, Max Planck Society;

External Resource

https://www.biorxiv.org/content/10.1101/2024.04.24.590549v1
(Preprint)

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Citation

Kotowska, A. M., Hiramatsu, F., Alexander, M. R., Scurr, D. J., Lightfoot, J. W., & Chauhan, V. M. (2024). Molecular surface chemistry defines nematode development, identity and behaviour. bioRxiv. doi:10.1101/2024.04.24.590549.


Cite as: https://hdl.handle.net/21.11116/0000-000F-639D-1
Abstract
Chemical signalling facilitates organismal communication and coordinates physiological and behavioural processes. In nematodes, chemical signalling has focused on secreted molecules leaving the surface’s communicative potential unexplored. Utilising 3D-OrbiSIMS surface-sensitive mass spectrometry, we directly characterise the molecular surface composition of Caenorhabditis elegans and Pristionchus pacificus. Their surfaces consist of a complex, lipid-dominated landscape with distinct developmental profiles and species-specific characteristics. These surface-anchored chemistries depend on the peroxisomal fatty acid β-oxidation component daf-22 and are essential for interaction-based behaviours including predation and kin-recognition. Specific lipid molecules identified as putative kin-recognition associated surface components include diglyceride (DG O-50:13), ceramide phosphate (CerP 41:1;O3), and hexosylceramide (HexCer 40:2;O3). Thus, we reveal the nematode surface is a dynamic signalling interface, pivotal for deciphering molecular mechanisms regulating development, identity and contact-dependent behaviour.