Genetic and environmental interactions contribute to immune variation in 
rewilded mice (advance online)

Oyesola, Oyebola; Downie, Alexander E.; Howard, Nina; Barre, Ramya S.; Kiwanuka, Kasalina; Zaldana, Kimberly; Chen, Ying-Han; Menezes, Arthur; Lee, Soo Ching; Devlin, Joseph; Mondragón-Palomino, Octavio; Souza, Camila Oliveira Silva; Herrmann, Christin; Koralov, Sergei B.; Cadwell, Ken; Graham, Andrea L.; Loke, P’ng

doi:10.1038/s41590-024-01862-5

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学術論文

Genetic and environmental interactions contribute to immune variation in rewilded mice (advance online)

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Downie, Alexander E.
Department of Primate Behavior and Evolution, Max Planck Institute for Evolutionary Anthropology, Max Planck Society;

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https://aclanthology.org/2024.lrec-main.925.pdf
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Oyesola_Genetic_NatImmol_2024.pdf
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引用

Oyesola, O., Downie, A. E., Howard, N., Barre, R. S., Kiwanuka, K., Zaldana, K., Chen, Y.-H., Menezes, A., Lee, S. C., Devlin, J., Mondragón-Palomino, O., Souza, C. O. S., Herrmann, C., Koralov, S. B., Cadwell, K., Graham, A. L., & Loke, P. (2024). Genetic and environmental interactions contribute to immune variation in rewilded mice (advance online). Nature Immunology. doi:10.1038/s41590-024-01862-5.

引用: https://hdl.handle.net/21.11116/0000-000F-78FE-D

要旨

The relative and synergistic contributions of genetics and environment to interindividual immune response variation remain unclear, despite implications in evolutionary biology and medicine. Here we quantify interactive effects of genotype and environment on immune traits by investigating C57BL/6, 129S1 and PWK/PhJ inbred mice, rewilded in an outdoor enclosure and infected with the parasite Trichuris muris. Whereas cellular composition was shaped by interactions between genotype and environment, cytokine response heterogeneity including IFNγ concentrations was primarily driven by genotype with consequence on worm burden. In addition, we show that other traits, such as expression of CD44, were explained mostly by genetics on T cells, whereas expression of CD44 on B cells was explained more by environment across all strains. Notably, genetic differences under laboratory conditions were decreased following rewilding. These results indicate that nonheritable influences interact with genetic factors to shape immune variation and parasite burden. © This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2024.