Human cortical neurogenesis is altered via glucocorticoid-mediated regulation 
of ZBTB16 expression

Krontira, Anthi C.; Cruceanu, Cristiana; Dony, Leander; Kyrousi, Christina; Link, Marie-Helen; Rek, Nils; Pöhlchen, Dorothee; Raimundo, Catarina; Penner-Goeke, Signe; Schowe, Alicia; Czamara, Darina; Lahti-Pulkkinen, Marius; Sammallahti, Sara; Wolford, Elina; Heinonen, Kati; Roeh, Simone; Sportelli, Vincenza; Woelfel, Barbara; Koedel, Maik; Sauer, Susann; Rex-Haffner, Monika; Raikkonen, Katri; Labeur, Marta; Cappello, Silvia; Binder, Elisabeth B.

doi:10.1016/j.neuron.2024.02.005

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

Human cortical neurogenesis is altered via glucocorticoid-mediated regulation of ZBTB16 expression

MPS-Authors

/persons/resource/persons262245

Krontira, Anthi C.
Dept. Genes and Environment, Max Planck Institute of Psychiatry, Max Planck Society;
IMPRS Translational Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons206456

Cruceanu, Cristiana
Dept. Genes and Environment, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons262330

Dony, Leander
Dept. Genes and Environment, Max Planck Institute of Psychiatry, Max Planck Society;
IMPRS Translational Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons226820

Kyrousi, Christina
Max Planck Research Group Developmental Neurobiology (Silvia Cappello), Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons299446

Link, Marie-Helen
Dept. Genes and Environment, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons227413

Rek, Nils
Dept. Genes and Environment, Max Planck Institute of Psychiatry, Max Planck Society;
IMPRS Translational Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons262423

Pöhlchen, Dorothee
Dept. Genes and Environment, Max Planck Institute of Psychiatry, Max Planck Society;
IMPRS Translational Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons299448

Raimundo, Catarina
Dept. Genes and Environment, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons223770

Penner-Goeke, Signe
Dept. Genes and Environment, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons297824

Schowe, Alicia
Dept. Genes and Environment, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons80291

Czamara, Darina
Dept. Genes and Environment, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons128467

Roeh, Simone
Dept. Genes and Environment, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons222201

Sportelli, Vincenza
Dept. Genes and Environment, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons80595

Woelfel, Barbara
Dept. Genes and Environment, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons222056

Koedel, Maik
Dept. Genes and Environment, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons226837

Sauer, Susann
Dept. Genes and Environment, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons80495

Rex-Haffner, Monika
Dept. Genes and Environment, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons80417

Labeur, Marta
Dept. Genes and Environment, Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons189184

Cappello, Silvia
Max Planck Research Group Developmental Neurobiology (Silvia Cappello), Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons80272

Binder, Elisabeth B.
Dept. Genes and Environment, Max Planck Institute of Psychiatry, Max Planck Society;

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Krontira, A. C., Cruceanu, C., Dony, L., Kyrousi, C., Link, M.-H., Rek, N., et al. (2024). Human cortical neurogenesis is altered via glucocorticoid-mediated regulation of ZBTB16 expression. NEURON, 112(9), 1426-1443.e11. doi:10.1016/j.neuron.2024.02.005.

Cite as: https://hdl.handle.net/21.11116/0000-000F-7A24-0

Abstract

Glucocorticoids are important for proper organ maturation, and their levels are tightly regulated during development. Here, we use human cerebral organoids and mice to study the cell -type -specific effects of glucocorticoids on neurogenesis. We show that glucocorticoids increase a specific type of basal progenitors (co -expressing PAX6 and EOMES) that has been shown to contribute to cortical expansion in gyrified species. This effect is mediated via the transcription factor ZBTB16 and leads to increased production of neurons. A phenome-wide Mendelian randomization analysis of an enhancer variant that moderates glucocorticoid-induced ZBTB16 levels reveals causal relationships with higher educational attainment and altered brain structure. The relationship with postnatal cognition is also supported by data from a prospective pregnancy cohort study. This work provides a cellular and molecular pathway for the effects of glucocorticoids on human neurogenesis that relates to lasting postnatal phenotypes.