date: 2024-10-11T11:41:31Z pdf:PDFVersion: 1.7 pdf:docinfo:title: “Small is beautiful” - Examining reliable determination of low-abundant therapeutic antibody glycovariants xmp:CreatorTool: Elsevier access_permission:can_print_degraded: true subject: Journal of Pharmaceutical Analysis, 14 (2024) 100982. doi:10.1016/j.jpha.2024.100982 language: en dc:format: application/pdf; version=1.7 pdf:docinfo:custom:robots: noindex pdf:docinfo:creator_tool: Elsevier access_permission:fill_in_form: true pdf:encrypted: false dc:title: “Small is beautiful” - Examining reliable determination of low-abundant therapeutic antibody glycovariants modified: 2024-10-11T11:41:31Z cp:subject: Journal of Pharmaceutical Analysis, 14 (2024) 100982. doi:10.1016/j.jpha.2024.100982 robots: noindex pdf:docinfo:custom:CrossMarkDomains[1]: sciencedirect.com pdf:docinfo:subject: Journal of Pharmaceutical Analysis, 14 (2024) 100982. doi:10.1016/j.jpha.2024.100982 pdf:docinfo:creator: Katharina Böttinger meta:author: Katharina Böttinger meta:creation-date: 2024-10-11T11:39:22Z pdf:docinfo:custom:CrossmarkMajorVersionDate: 2010-04-23 created: 2024-10-11T11:39:22Z access_permission:extract_for_accessibility: true Creation-Date: 2024-10-11T11:39:22Z pdf:docinfo:custom:CrossMarkDomains[2]: elsevier.com ElsevierWebPDFSpecifications: 7.0.1 pdf:docinfo:custom:doi: 10.1016/j.jpha.2024.100982 pdf:docinfo:custom:CrossmarkDomainExclusive: true Author: Katharina Böttinger producer: Acrobat Distiller 8.1.0 (Windows) CrossmarkDomainExclusive: true pdf:docinfo:producer: Acrobat Distiller 8.1.0 (Windows) doi: 10.1016/j.jpha.2024.100982 pdf:unmappedUnicodeCharsPerPage: 1 access_permission:modify_annotations: true dc:creator: Katharina Böttinger dcterms:created: 2024-10-11T11:39:22Z Last-Modified: 2024-10-11T11:41:31Z dcterms:modified: 2024-10-11T11:41:31Z title: “Small is beautiful” - Examining reliable determination of low-abundant therapeutic antibody glycovariants Last-Save-Date: 2024-10-11T11:41:31Z CrossMarkDomains[1]: sciencedirect.com pdf:docinfo:modified: 2024-10-11T11:41:31Z meta:save-date: 2024-10-11T11:41:31Z Content-Type: application/pdf X-Parsed-By: org.apache.tika.parser.DefaultParser creator: Katharina Böttinger dc:language: en X-TIKA:EXCEPTION:warn: org.xml.sax.SAXParseException; lineNumber: 77; columnNumber: 11; The content of elements must consist of well-formed character data or markup. at org.apache.xerces@2.12.0.SP03//org.apache.xerces.parsers.DOMParser.parse(DOMParser.java:245) at org.apache.xerces@2.12.0.SP03//org.apache.xerces.jaxp.DocumentBuilderImpl.parse(DocumentBuilderImpl.java:298) at java.xml/javax.xml.parsers.DocumentBuilder.parse(DocumentBuilder.java:122) at deployment.pubman_ear-8.5.4-SNAPSHOT.ear//org.apache.tika.utils.XMLReaderUtils.buildDOM(XMLReaderUtils.java:407) at deployment.pubman_ear-8.5.4-SNAPSHOT.ear//org.apache.tika.parser.pdf.PDFParser.loadDOM(PDFParser.java:744) at deployment.pubman_ear-8.5.4-SNAPSHOT.ear//org.apache.tika.parser.pdf.PDFParser.extractMetadata(PDFParser.java:234) at deployment.pubman_ear-8.5.4-SNAPSHOT.ear//org.apache.tika.parser.pdf.PDFParser.parse(PDFParser.java:159) at deployment.pubman_ear-8.5.4-SNAPSHOT.ear//org.apache.tika.parser.CompositeParser.parse(CompositeParser.java:280) at deployment.pubman_ear-8.5.4-SNAPSHOT.ear//org.apache.tika.parser.CompositeParser.parse(CompositeParser.java:280) at deployment.pubman_ear-8.5.4-SNAPSHOT.ear//org.apache.tika.parser.AutoDetectParser.parse(AutoDetectParser.java:143) at deployment.pubman_ear-8.5.4-SNAPSHOT.ear//de.mpg.mpdl.inge.service.pubman.impl.FileServiceFSImpl.getFileMetadata(FileServiceFSImpl.java:449) at jdk.internal.reflect.GeneratedMethodAccessor821.invoke(Unknown Source) at java.base/jdk.internal.reflect.DelegatingMethodAccessorImpl.invoke(DelegatingMethodAccessorImpl.java:43) at java.base/java.lang.reflect.Method.invoke(Method.java:569) at deployment.pubman_ear-8.5.4-SNAPSHOT.ear//org.springframework.aop.support.AopUtils.invokeJoinpointUsingReflection(AopUtils.java:344) at deployment.pubman_ear-8.5.4-SNAPSHOT.ear//org.springframework.aop.framework.JdkDynamicAopProxy.invoke(JdkDynamicAopProxy.java:208) at deployment.pubman_ear-8.5.4-SNAPSHOT.ear.de.mpg.mpdl.inge-pubman_presentation-8.5.4-SNAPSHOT.war/jdk.proxy12/jdk.proxy12.$Proxy184.getFileMetadata(Unknown Source) at deployment.pubman_ear-8.5.4-SNAPSHOT.ear.de.mpg.mpdl.inge-pubman_rest-8.5.4-SNAPSHOT.war//de.mpg.mpdl.inge.rest.web.controller.ItemRestController.getTechnicalMetadataByTika(ItemRestController.java:301) at jdk.internal.reflect.GeneratedMethodAccessor820.invoke(Unknown Source) at java.base/jdk.internal.reflect.DelegatingMethodAccessorImpl.invoke(DelegatingMethodAccessorImpl.java:43) at java.base/java.lang.reflect.Method.invoke(Method.java:569) at deployment.pubman_ear-8.5.4-SNAPSHOT.ear//org.springframework.web.method.support.InvocableHandlerMethod.doInvoke(InvocableHandlerMethod.java:205) at deployment.pubman_ear-8.5.4-SNAPSHOT.ear//org.springframework.web.method.support.InvocableHandlerMethod.invokeForRequest(InvocableHandlerMethod.java:150) at deployment.pubman_ear-8.5.4-SNAPSHOT.ear//org.springframework.web.servlet.mvc.method.annotation.ServletInvocableHandlerMethod.invokeAndHandle(ServletInvocableHandlerMethod.java:117) at deployment.pubman_ear-8.5.4-SNAPSHOT.ear//org.springframework.web.servlet.mvc.method.annotation.RequestMappingHandlerAdapter.invokeHandlerMethod(RequestMappingHandlerAdapter.java:895) at deployment.pubman_ear-8.5.4-SNAPSHOT.ear//org.springframework.web.servlet.mvc.method.annotation.RequestMappingHandlerAdapter.handleInternal(RequestMappingHandlerAdapter.java:808) at deployment.pubman_ear-8.5.4-SNAPSHOT.ear//org.springframework.web.servlet.mvc.method.AbstractHandlerMethodAdapter.handle(AbstractHandlerMethodAdapter.java:87) at deployment.pubman_ear-8.5.4-SNAPSHOT.ear//org.springframework.web.servlet.DispatcherServlet.doDispatch(DispatcherServlet.java:1071) at deployment.pubman_ear-8.5.4-SNAPSHOT.ear//org.springframework.web.servlet.DispatcherServlet.doService(DispatcherServlet.java:964) at deployment.pubman_ear-8.5.4-SNAPSHOT.ear//org.springframework.web.servlet.FrameworkServlet.processRequest(FrameworkServlet.java:1006) at deployment.pubman_ear-8.5.4-SNAPSHOT.ear//org.springframework.web.servlet.FrameworkServlet.doGet(FrameworkServlet.java:898) at javax.servlet.api@2.0.0.Final//javax.servlet.http.HttpServlet.service(HttpServlet.java:503) at deployment.pubman_ear-8.5.4-SNAPSHOT.ear//org.springframework.web.servlet.FrameworkServlet.service(FrameworkServlet.java:883) at javax.servlet.api@2.0.0.Final//javax.servlet.http.HttpServlet.service(HttpServlet.java:590) at io.undertow.servlet@2.2.19.Final//io.undertow.servlet.handlers.ServletHandler.handleRequest(ServletHandler.java:74) at io.undertow.servlet@2.2.19.Final//io.undertow.servlet.handlers.FilterHandler$FilterChainImpl.doFilter(FilterHandler.java:129) at deployment.pubman_ear-8.5.4-SNAPSHOT.ear.de.mpg.mpdl.inge-pubman_rest-8.5.4-SNAPSHOT.war//de.mpg.mpdl.inge.rest.web.spring.AuthCookieToHeaderFilter.doFilter(AuthCookieToHeaderFilter.java:112) at io.undertow.servlet@2.2.19.Final//io.undertow.servlet.core.ManagedFilter.doFilter(ManagedFilter.java:61) at io.undertow.servlet@2.2.19.Final//io.undertow.servlet.handlers.FilterHandler$FilterChainImpl.doFilter(FilterHandler.java:131) at deployment.pubman_ear-8.5.4-SNAPSHOT.ear//org.springframework.web.filter.CharacterEncodingFilter.doFilterInternal(CharacterEncodingFilter.java:201) at deployment.pubman_ear-8.5.4-SNAPSHOT.ear//org.springframework.web.filter.OncePerRequestFilter.doFilter(OncePerRequestFilter.java:117) at io.undertow.servlet@2.2.19.Final//io.undertow.servlet.core.ManagedFilter.doFilter(ManagedFilter.java:61) at io.undertow.servlet@2.2.19.Final//io.undertow.servlet.handlers.FilterHandler$FilterChainImpl.doFilter(FilterHandler.java:131) at io.undertow.servlet@2.2.19.Final//io.undertow.servlet.handlers.FilterHandler.handleRequest(FilterHandler.java:84) at io.undertow.servlet@2.2.19.Final//io.undertow.servlet.handlers.security.ServletSecurityRoleHandler.handleRequest(ServletSecurityRoleHandler.java:62) at io.undertow.servlet@2.2.19.Final//io.undertow.servlet.handlers.ServletChain$1.handleRequest(ServletChain.java:68) at io.undertow.servlet@2.2.19.Final//io.undertow.servlet.handlers.ServletDispatchingHandler.handleRequest(ServletDispatchingHandler.java:36) at org.wildfly.security.elytron-web.undertow-server@1.10.1.Final//org.wildfly.elytron.web.undertow.server.ElytronRunAsHandler.lambda$handleRequest$1(ElytronRunAsHandler.java:68) at org.wildfly.security.elytron-base@1.19.1.Final//org.wildfly.security.auth.server.FlexibleIdentityAssociation.runAsFunctionEx(FlexibleIdentityAssociation.java:103) at org.wildfly.security.elytron-base@1.19.1.Final//org.wildfly.security.auth.server.Scoped.runAsFunctionEx(Scoped.java:161) at org.wildfly.security.elytron-base@1.19.1.Final//org.wildfly.security.auth.server.Scoped.runAs(Scoped.java:73) at org.wildfly.security.elytron-web.undertow-server@1.10.1.Final//org.wildfly.elytron.web.undertow.server.ElytronRunAsHandler.handleRequest(ElytronRunAsHandler.java:67) at io.undertow.servlet@2.2.19.Final//io.undertow.servlet.handlers.RedirectDirHandler.handleRequest(RedirectDirHandler.java:68) at io.undertow.servlet@2.2.19.Final//io.undertow.servlet.handlers.security.SSLInformationAssociationHandler.handleRequest(SSLInformationAssociationHandler.java:117) at io.undertow.servlet@2.2.19.Final//io.undertow.servlet.handlers.security.ServletAuthenticationCallHandler.handleRequest(ServletAuthenticationCallHandler.java:57) at io.undertow.core@2.2.19.Final//io.undertow.server.handlers.PredicateHandler.handleRequest(PredicateHandler.java:43) at io.undertow.core@2.2.19.Final//io.undertow.security.handlers.AbstractConfidentialityHandler.handleRequest(AbstractConfidentialityHandler.java:46) at io.undertow.servlet@2.2.19.Final//io.undertow.servlet.handlers.security.ServletConfidentialityConstraintHandler.handleRequest(ServletConfidentialityConstraintHandler.java:64) at io.undertow.core@2.2.19.Final//io.undertow.security.handlers.AbstractSecurityContextAssociationHandler.handleRequest(AbstractSecurityContextAssociationHandler.java:43) at org.wildfly.security.elytron-web.undertow-server-servlet@1.10.1.Final//org.wildfly.elytron.web.undertow.server.servlet.CleanUpHandler.handleRequest(CleanUpHandler.java:38) at io.undertow.core@2.2.19.Final//io.undertow.server.handlers.PredicateHandler.handleRequest(PredicateHandler.java:43) at org.wildfly.extension.undertow@26.1.3.Final//org.wildfly.extension.undertow.security.jacc.JACCContextIdHandler.handleRequest(JACCContextIdHandler.java:61) at io.undertow.core@2.2.19.Final//io.undertow.server.handlers.PredicateHandler.handleRequest(PredicateHandler.java:43) at org.wildfly.extension.undertow@26.1.3.Final//org.wildfly.extension.undertow.deployment.GlobalRequestControllerHandler.handleRequest(GlobalRequestControllerHandler.java:68) at io.undertow.servlet@2.2.19.Final//io.undertow.servlet.handlers.SendErrorPageHandler.handleRequest(SendErrorPageHandler.java:52) at io.undertow.core@2.2.19.Final//io.undertow.server.handlers.PredicateHandler.handleRequest(PredicateHandler.java:43) at io.undertow.servlet@2.2.19.Final//io.undertow.servlet.handlers.ServletInitialHandler.handleFirstRequest(ServletInitialHandler.java:275) at io.undertow.servlet@2.2.19.Final//io.undertow.servlet.handlers.ServletInitialHandler.access$100(ServletInitialHandler.java:79) at io.undertow.servlet@2.2.19.Final//io.undertow.servlet.handlers.ServletInitialHandler$2.call(ServletInitialHandler.java:134) at io.undertow.servlet@2.2.19.Final//io.undertow.servlet.handlers.ServletInitialHandler$2.call(ServletInitialHandler.java:131) at io.undertow.servlet@2.2.19.Final//io.undertow.servlet.core.ServletRequestContextThreadSetupAction$1.call(ServletRequestContextThreadSetupAction.java:48) at io.undertow.servlet@2.2.19.Final//io.undertow.servlet.core.ContextClassLoaderSetupAction$1.call(ContextClassLoaderSetupAction.java:43) at org.wildfly.extension.undertow@26.1.3.Final//org.wildfly.extension.undertow.deployment.UndertowDeploymentInfoService$UndertowThreadSetupAction.lambda$create$0(UndertowDeploymentInfoService.java:1544) at org.wildfly.extension.undertow@26.1.3.Final//org.wildfly.extension.undertow.deployment.UndertowDeploymentInfoService$UndertowThreadSetupAction.lambda$create$0(UndertowDeploymentInfoService.java:1544) at org.wildfly.extension.undertow@26.1.3.Final//org.wildfly.extension.undertow.deployment.UndertowDeploymentInfoService$UndertowThreadSetupAction.lambda$create$0(UndertowDeploymentInfoService.java:1544) at io.undertow.servlet@2.2.19.Final//io.undertow.servlet.handlers.ServletInitialHandler.dispatchRequest(ServletInitialHandler.java:255) at io.undertow.servlet@2.2.19.Final//io.undertow.servlet.handlers.ServletInitialHandler.access$000(ServletInitialHandler.java:79) at io.undertow.servlet@2.2.19.Final//io.undertow.servlet.handlers.ServletInitialHandler$1.handleRequest(ServletInitialHandler.java:100) at io.undertow.core@2.2.19.Final//io.undertow.server.Connectors.executeRootHandler(Connectors.java:387) at io.undertow.core@2.2.19.Final//io.undertow.server.HttpServerExchange$1.run(HttpServerExchange.java:852) at org.jboss.threads@2.4.0.Final//org.jboss.threads.ContextClassLoaderSavingRunnable.run(ContextClassLoaderSavingRunnable.java:35) at org.jboss.threads@2.4.0.Final//org.jboss.threads.EnhancedQueueExecutor.safeRun(EnhancedQueueExecutor.java:1990) at org.jboss.threads@2.4.0.Final//org.jboss.threads.EnhancedQueueExecutor$ThreadBody.doRunTask(EnhancedQueueExecutor.java:1486) at org.jboss.threads@2.4.0.Final//org.jboss.threads.EnhancedQueueExecutor$ThreadBody.run(EnhancedQueueExecutor.java:1377) at org.jboss.xnio@3.8.7.Final//org.xnio.XnioWorker$WorkerThreadFactory$1$1.run(XnioWorker.java:1282) at java.base/java.lang.Thread.run(Thread.java:840) pdf:docinfo:custom:ElsevierWebPDFSpecifications: 7.0.1 access_permission:assemble_document: true xmpTPg:NPages: 15 pdf:charsPerPage: 4501 access_permission:extract_content: true access_permission:can_print: true CrossMarkDomains[2]: elsevier.com access_permission:can_modify: true pdf:docinfo:created: 2024-10-11T11:39:22Z CrossmarkMajorVersionDate: 2010-04-23