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Journal Article

“Naked Nickel”-Catalyzed Amination of Heteroaryl Bromides

MPS-Authors
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Saeb,  Rakan
Research Group Cornellà, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

Boulenger,  Bryan
Research Group Cornellà, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Cornella,  Josep
Research Group Cornellà, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Citation

Saeb, R., Boulenger, B., & Cornella, J. (2024). “Naked Nickel”-Catalyzed Amination of Heteroaryl Bromides. Organic Letters. doi:10.1021/acs.orglett.4c01738.


Cite as: https://hdl.handle.net/21.11116/0000-000F-8D7F-5
Abstract
In this Letter, we report that the air-stable “naked nickel” [Ni(4-tBustb)3] is a competent catalyst in thermal C–N bond formation between (hetero)aryl bromides and N-based nucleophiles. The catalytic system is characterized by a “naked nickel” complex and Zn and by the absence of external light sources, photocatalysts, exogenous ligands, and electrical setups. Upon application of this method, various heteroaryls bearing Lewis-basic heteroatoms can be accommodated and directly aminated with a set of primary and secondary amines.