Stress-sensitive neural circuits change the gut microbiome via duodenal glands

Chang, H; Perkins, MH; Novaes, LS; Qian, F; Zhang, T; Neckel, PH; Ley, RE; Han, W; De Araújo, IE

doi:10.1016/j.cell.2024.07.019

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

Stress-sensitive neural circuits change the gut microbiome via duodenal glands

MPS-Authors

/persons/resource/persons270516

Ley, RE
Department Microbiome Science, Max Planck Institute for Biology Tübingen, Max Planck Society;

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Chang, H., Perkins, M., Novaes, L., Qian, F., Zhang, T., Neckel, P., et al. (2024). Stress-sensitive neural circuits change the gut microbiome via duodenal glands. Cell, 187(19), 5393-5412. doi:10.1016/j.cell.2024.07.019.

Cite as: https://hdl.handle.net/21.11116/0000-000F-B0A8-C

Abstract

Negative psychological states impact immunity by altering the gut microbiome. However, the relationship between brain states and microbiome composition remains unclear. We show that Brunner's glands in the duodenum couple stress-sensitive brain circuits to bacterial homeostasis. Brunner's glands mediated the enrichment of gut Lactobacillus species in response to vagus nerve stimulation. Cell-specific ablation of the glands markedly suppressed Lactobacilli counts and heightened vulnerability to infection. In the forebrain, we mapped a vagally mediated, polysynaptic circuit connecting the central nucleus of the amygdala to Brunner's glands. Chronic stress suppressed central amygdala activity and phenocopied the effects of gland lesions. Conversely, excitation of either the central amygdala or parasympathetic vagal neurons activated Brunner's glands and reversed the effects of stress on the gut microbiome and immunity. The findings revealed a tractable brain-body mechanism linking psychological states to host defense.