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Journal Article

Optimized platform for automated glycan assembly

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Danglad-Flores,  José Angél       
Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Sletten,  Eric T.
Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Reuber,  Emelie
Peter H. Seeberger - Vaccine Development, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Bienert,  Klaus
Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Seeberger,  Peter H.       
Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Citation

Danglad-Flores, J. A., Sletten, E. T., Reuber, E., Bienert, K., Riegler, H., & Seeberger, P. H. (2024). Optimized platform for automated glycan assembly. Device, 100499. doi:10.1016/j.device.2024.100499.


Cite as: https://hdl.handle.net/21.11116/0000-000F-B480-4
Abstract
Fast, affordable, and reliable access to complex glycans is essential to meet the demand for custom-made research tools for glycosciences. Automated glycan assembly (AGA), based on the solid-phase synthesis paradigm allows quickly producing a range of biologically relevant oligosaccharides. The instrument sets the limits as to the types of chemistries that can be executed. The new, smaller, and more economical synthesis device allows quick temperature adjustments between −40°C and +90°C based on an energy-efficient local-temperature-controlled (LTC) reactor. The power of the new instrument is illustrated in the context of several AGA syntheses of complex oligosaccharides.