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Targeting modular polyketide synthases with iteratively acting acyltransferases from metagenomes of uncultured bacterial consortia

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Piel,  J.
Department of Bioorganic Chemistry, MPI for Chemical Ecology, Max Planck Society;

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Hui,  D. Q.
Department of Bioorganic Chemistry, MPI for Chemical Ecology, Max Planck Society;

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引用

Piel, J., Hui, D. Q., Fusetani, N., & Matsunaga, S. (2004). Targeting modular polyketide synthases with iteratively acting acyltransferases from metagenomes of uncultured bacterial consortia. Environmental Microbiology, 6(9), 921-927. doi:10.1111/j.1462-2920.2004.00531.x.


引用: https://hdl.handle.net/11858/00-001M-0000-0012-A289-1
要旨
Bacterial type I polyketide synthases (PKSs) produce a wide range of biomedically important secondary metabolites. These enzymes possess a modular structure that can be genetically re-engineered to yield novel drug candidates not found in nature. Recent