A Ca-dependent early step in the release of catecholamines from adrenal 
chromaffin cells

von Rueden, L.; Neher, E.

doi:10.1126/science.8235626

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

A Ca-dependent early step in the release of catecholamines from adrenal chromaffin cells

MPS-Authors

/persons/resource/persons15971

von Rueden, L.
Department of Membrane Biophysics, MPI for biophysical chemistry, Max Planck Society;

/persons/resource/persons15570

Neher, E.
Department of Membrane Biophysics, MPI for biophysical chemistry, Max Planck Society;

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

von Rueden, L., & Neher, E. (1993). A Ca-dependent early step in the release of catecholamines from adrenal chromaffin cells. Science, 262(5136), 1061-1065. doi:10.1126/science.8235626.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0013-0693-F

Abstract

Intense stimuli, such as trains of depolarizing pulses or the caffeine-induced release of calcium from intracellular stores, readily depress the secretory response in neuroendocrine cells. Secretory responses are restored by rest periods of minutes in duration. This recovery was accelerated when the concentration of cytosolic calcium was moderately increased and probably resulted from calcium-dependent replenishment of a pool of release-ready granules. Continuously increased concentrations of calcium led to the overfilling of such a pool. Subsequently, secretory responses to stronger calcium stimuli were augmented. Hormone-induced calcium transients with a plateau phase of increased concentration of calcium may enhance the secretory response in this way.