Spatial attention related SEP amplitude modulations covary with BOLD signal in 
S1-a simultaneous EEG-fMRI study

Schubert, Ruth; Ritter, Petra; Wüstenberg, Torsten; Preuschhof, Claudia; Curio, Gabriel; Sommer, Werner; Villringer, Arno

doi:10.1093/cercor/bhn029

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Spatial attention related SEP amplitude modulations covary with BOLD signal in S1-a simultaneous EEG-fMRI study

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Villringer, Arno
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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https://doi.org/10.1093/cercor/bhn029
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Citation

Schubert, R., Ritter, P., Wüstenberg, T., Preuschhof, C., Curio, G., Sommer, W., et al. (2008). Spatial attention related SEP amplitude modulations covary with BOLD signal in S1-a simultaneous EEG-fMRI study. Cerebral Cortex, 18(11), 2686-2700. doi:10.1093/cercor/bhn029.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0010-DA97-E

Abstract

Recent studies investigating the influence of spatial-selective attention on primary somatosensory processing have produced inconsistent results. The aim of this study was to explore the influence of tactile spatial-selective attention on spatiotemporal aspects of evoked neuronal activity in the primary somatosensory cortex (S1). We employed simultaneous electroencephalography (EEG)-functional magnetic resonance imaging (fMRI) in 14 right-handed subjects during bilateral index finger Braille stimulation to investigate the relationship between attentional effects on somatosensory evoked potential (SEP) components and the blood oxygenation level-dependent (BOLD) signal. The 1st reliable EEG response following left tactile stimulation (P50) was significantly enhanced by spatial-selective attention, which has not been reported before. FMRI analysis revealed increased activity in contralateral S1. Remarkably, the effect of attention on the P50 component as well as long-latency SEP components starting at 190 ms for left stimuli correlated with attentional effects on the BOLD signal in contralateral S1. The implications are 2-fold: First, the correlation between early and long-latency SEP components and the BOLD effect suggest that spatial-selective attention enhances processing in S1 at 2 time points: During an early passage of the signal and during a later passage, probably via re-entrant feedback from higher cortical areas. Second, attentional modulations of the fast electrophysiological signals and the slow hemodynamic response are linearly related in S1. © The Author 2008. Published by Oxford University Press. All rights reserved.