date: 2010-06-24T10:58:44Z
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pdf:docinfo:title: Neuroanatomical Prerequisites for Language Functions in the Maturing Brain
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subject: The 2 major language-relevant cortical regions in the human brain, Broca's area and Wernicke's area, are connected via the fibers of the arcuate fasciculus/superior longitudinal fasciculus (AF/SLF). Here, we compared this pathway in adults and children and its relation to language processing during development. Comparison of fiber properties demonstrated lower anisotropy in children's AF/SLF, arguing for an immature status of this particular pathway with conceivably a lower degree of myelination. Combined diffusion tensor imaging (DTI) data and functional magnetic resonance imaging (fMRI) data indicated that in adults the termination of the AF/SLF fiber projection is compatible with functional activation in Broca's area, that is pars opercularis. In children, activation in Broca's area extended from the pars opercularis into the pars triangularis revealing an alternative connection to the temporal lobe (Wernicke's area) via the ventrally projecting extreme capsule fiber system. fMRI and DTI data converge to indicate that adults make use of a more confined language network than children based on ongoing maturation of the structural network. Our data suggest relations between language development and brain maturation and, moreover, indicate the brain's plasticity to adjust its function to available structural prerequisites.
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dc:title: Neuroanatomical Prerequisites for Language Functions in the Maturing Brain
bibtex/file: Brauer_CerebCortex_preprint_2010.pdf:Brauer_CerebCortex_preprint_2010.pdf:PDF
modified: 2010-06-24T10:58:44Z
cp:subject: The 2 major language-relevant cortical regions in the human brain, Broca's area and Wernicke's area, are connected via the fibers of the arcuate fasciculus/superior longitudinal fasciculus (AF/SLF). Here, we compared this pathway in adults and children and its relation to language processing during development. Comparison of fiber properties demonstrated lower anisotropy in children's AF/SLF, arguing for an immature status of this particular pathway with conceivably a lower degree of myelination. Combined diffusion tensor imaging (DTI) data and functional magnetic resonance imaging (fMRI) data indicated that in adults the termination of the AF/SLF fiber projection is compatible with functional activation in Broca's area, that is pars opercularis. In children, activation in Broca's area extended from the pars opercularis into the pars triangularis revealing an alternative connection to the temporal lobe (Wernicke's area) via the ventrally projecting extreme capsule fiber system. fMRI and DTI data converge to indicate that adults make use of a more confined language network than children based on ongoing maturation of the structural network. Our data suggest relations between language development and brain maturation and, moreover, indicate the brain's plasticity to adjust its function to available structural prerequisites.
pdf:docinfo:subject: The 2 major language-relevant cortical regions in the human brain, Broca's area and Wernicke's area, are connected via the fibers of the arcuate fasciculus/superior longitudinal fasciculus (AF/SLF). Here, we compared this pathway in adults and children and its relation to language processing during development. Comparison of fiber properties demonstrated lower anisotropy in children's AF/SLF, arguing for an immature status of this particular pathway with conceivably a lower degree of myelination. Combined diffusion tensor imaging (DTI) data and functional magnetic resonance imaging (fMRI) data indicated that in adults the termination of the AF/SLF fiber projection is compatible with functional activation in Broca's area, that is pars opercularis. In children, activation in Broca's area extended from the pars opercularis into the pars triangularis revealing an alternative connection to the temporal lobe (Wernicke's area) via the ventrally projecting extreme capsule fiber system. fMRI and DTI data converge to indicate that adults make use of a more confined language network than children based on ongoing maturation of the structural network. Our data suggest relations between language development and brain maturation and, moreover, indicate the brain's plasticity to adjust its function to available structural prerequisites.
pdf:docinfo:creator: Brauer, Jens and Anwander, Alfred and Friederici, Angela D.
pdf:docinfo:custom:bibtex/timestamp: 2010.06.22
meta:author: Jens Brauer
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pdf:docinfo:custom:bibtex/eprint: http://cercor.oxfordjournals.org/cgi/reprint/bhq108v1.pdf
Author: Jens Brauer
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bibtex/doi: 10.1093/cercor/bhq108
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dc:description: The 2 major language-relevant cortical regions in the human brain, Broca's area and Wernicke's area, are connected via the fibers of the arcuate fasciculus/superior longitudinal fasciculus (AF/SLF). Here, we compared this pathway in adults and children and its relation to language processing during development. Comparison of fiber properties demonstrated lower anisotropy in children's AF/SLF, arguing for an immature status of this particular pathway with conceivably a lower degree of myelination. Combined diffusion tensor imaging (DTI) data and functional magnetic resonance imaging (fMRI) data indicated that in adults the termination of the AF/SLF fiber projection is compatible with functional activation in Broca's area, that is pars opercularis. In children, activation in Broca's area extended from the pars opercularis into the pars triangularis revealing an alternative connection to the temporal lobe (Wernicke's area) via the ventrally projecting extreme capsule fiber system. fMRI and DTI data converge to indicate that adults make use of a more confined language network than children based on ongoing maturation of the structural network. Our data suggest relations between language development and brain maturation and, moreover, indicate the brain's plasticity to adjust its function to available structural prerequisites.
Keywords: development, DTI, fiber tractography, fMRI, language
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dc:creator: Jens Brauer
description: The 2 major language-relevant cortical regions in the human brain, Broca's area and Wernicke's area, are connected via the fibers of the arcuate fasciculus/superior longitudinal fasciculus (AF/SLF). Here, we compared this pathway in adults and children and its relation to language processing during development. Comparison of fiber properties demonstrated lower anisotropy in children's AF/SLF, arguing for an immature status of this particular pathway with conceivably a lower degree of myelination. Combined diffusion tensor imaging (DTI) data and functional magnetic resonance imaging (fMRI) data indicated that in adults the termination of the AF/SLF fiber projection is compatible with functional activation in Broca's area, that is pars opercularis. In children, activation in Broca's area extended from the pars opercularis into the pars triangularis revealing an alternative connection to the temporal lobe (Wernicke's area) via the ventrally projecting extreme capsule fiber system. fMRI and DTI data converge to indicate that adults make use of a more confined language network than children based on ongoing maturation of the structural network. Our data suggest relations between language development and brain maturation and, moreover, indicate the brain's plasticity to adjust its function to available structural prerequisites.
dcterms:created: 2010-06-24T10:58:44Z
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dcterms:modified: 2010-06-24T10:58:44Z
title: Neuroanatomical Prerequisites for Language Functions in the Maturing Brain
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pdf:docinfo:keywords: development, DTI, fiber tractography, fMRI, language
pdf:docinfo:modified: 2010-06-24T10:58:44Z
pdf:docinfo:custom:bibtex/year: 2010
meta:save-date: 2010-06-24T10:58:44Z
bibtex/bibtexkey: Brauer_CerebCortex_preprint_2010
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creator: Jens Brauer
dc:subject: development, DTI, fiber tractography, fMRI, language
bibtex/journal: Cereb Cortex
pdf:docinfo:custom:bibtex/journal: Cereb Cortex
bibtex/eprint: http://cercor.oxfordjournals.org/cgi/reprint/bhq108v1.pdf
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bibtex/url: http://cercor.oxfordjournals.org/cgi/content/abstract/bhq108v1
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pdf:docinfo:custom:bibtex/url: http://cercor.oxfordjournals.org/cgi/content/abstract/bhq108v1
bibtex/year: 2010
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meta:keyword: development, DTI, fiber tractography, fMRI, language
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pdf:docinfo:created: 2010-06-24T10:58:44Z