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keywords: interactomics, quantitative mass spectrometry, Piezo2, vertebrate mechanotransduction, rapidly adapting mechanically activated currents
dc.Type: research-article
dc.Title: Native Piezo2 Interactomics Identifies Pericentrin as a Novel Regulator of Piezo2 in Somatosensory Neurons
dc.Identifier: 10.1021/acs.jproteome.6b00235
title: Native Piezo2 Interactomics Identifies Pericentrin as a Novel Regulator of Piezo2 in Somatosensory Neurons - Journal of Proteome Research (ACS Publications)
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dc.Publisher: American Chemical Society
dc.Language: EN
dc.Description: The ability of somatosensory neurons to perceive mechanical stimuli relies on specialized mechanotransducing proteins and their molecular environment. Only recently has the identity of a major transducer of mechanical forces in vertebrates been revealed by the discovery of Piezo2. Further work has established its pivotal role for innocuous touch in mice. Therefore, Piezo2 offers a unique platform for the molecular investigation of somatosensory mechanosensation. We performed a mass spectrometry-based interactomics screen on native Piezo2 in somatosensory neurons of mouse dorsal root ganglia (DRG). Stringent and quantitative data analysis yielded the identity of 36 novel binding partners of Piezo2. The biological significance of this data set is reflected by functional experiments demonstrating a role for Pericentrin in modulating Piezo2 activity and membrane expression in somatosensory neurons. Collectively, our findings provide a framework for understanding Piezo2 physiology and serve as a rich resource ...
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dc:title: Native Piezo2 Interactomics Identifies Pericentrin as a Novel Regulator of Piezo2 in Somatosensory Neurons - Journal of Proteome Research (ACS Publications)
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dc.Creator: Pratibha Narayanan
dc.Date: July 11, 2016
dc.Coverage: world
dc.Subject: interactomics; quantitative mass spectrometry; Piezo2; vertebrate mechanotransduction; rapidly adapting mechanically activated currents
Content-Language: en
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