Video 1: Conformational changes between free Pol I and Pol I EC

FromStructure of RNA polymerase I transcribing ribosomal DNA genes

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The video illustrates the transition from free monomeric Pol I to elongating Pol I. The four major polymerase modules core, jaw-lobe, clamp and shelf are colored in grey, blue, yellow and pink, respectively. The movement of the rigid clamp-shelf module is highlighted together with the refolding of the bridge helix (green). The adjacent dimer of model of the crystal structure (PDB 4C2M) is shown briefly before the focus is set on the domain movements. Furthermore, the expander (light green), downstream DNA (blue), the DNA-RNA hybrid (blue-red) and the C-terminal domain of A12.2 are visualized.

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