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Proteasomes tether to two distinct sites at the nuclear pore complex
Sahradha Albert, Miroslava Schaffer, Florian Beck, Shyamal Mosalaganti, Shoh Asano, Henry F. Thomas, Jürgen M. Plitzko, Martin Beck, Wolfgang Baumeister and Benjamin D. Engel
Sahradha Albert
aDepartment of Molecular Structural Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany;
Miroslava Schaffer
aDepartment of Molecular Structural Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany;
Florian Beck
aDepartment of Molecular Structural Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany;
Shyamal Mosalaganti
bStructural and Computational Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany
Shoh Asano
aDepartment of Molecular Structural Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany;
Henry F. Thomas
aDepartment of Molecular Structural Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany;
Jürgen M. Plitzko
aDepartment of Molecular Structural Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany;
Martin Beck
bStructural and Computational Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany
Wolfgang Baumeister
aDepartment of Molecular Structural Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany;
Benjamin D. Engel
aDepartment of Molecular Structural Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany;
Supporting Information
- Download Supporting Information (PDF)
- Download Movie_S01 (MOV) - Sequential sections back and forth through the tomographic volume shown in Fig. 1A (orthographic view), followed by reveal of the 3D segmentation from Fig. 1B (perspective view). Each class of assembly states, functional states, and binding states is then mapped into the cellular volume, as in Fig. S6.
- Download Movie_S02 (MOV) - Orthographic nuclear views of NPCs (purple) showing double-capped (dark purple) and single-capped (lavender) assembly states, followed by ground (green), substrate-processing (pink), and unknown (dark gray) functional states, followed by free (light blue), basket-tethered (yellow), and membrane-tethered (orange) binding states. This movie accompanies Fig. 3C.