date: 2019-04-09T10:22:50Z
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pdf:docinfo:title: Cationic Albumin Encapsulated DNA Origami for Enhanced Cellular Transfection and Stability
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subject: DNA nanostructures, owing to their controllable and adaptable nature, have been considered as highly attractive nanoplatforms for biomedical applications in recent years. However, their use in the biological environment has been restricted by low cellular transfection efficiency in mammalian cells, weak stability under physiological conditions, and endonuclease degradation. Herein, we demonstrate an effective approach to facilitate fast transfection of DNA nanostructures and enhance their stability by encapsulating DNA origami with a biocompatible cationic protein (cHSA) via electrostatic interaction. The coated DNA origami is found to be stable under physiological conditions. Moreover, the cHSA coating could significantly improve the cellular transfection efficiency of DNA origami, which is essential for biological applications.
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dc:title: Cationic Albumin Encapsulated DNA Origami for Enhanced Cellular Transfection and Stability
modified: 2019-04-09T10:22:50Z
cp:subject: DNA nanostructures, owing to their controllable and adaptable nature, have been considered as highly attractive nanoplatforms for biomedical applications in recent years. However, their use in the biological environment has been restricted by low cellular transfection efficiency in mammalian cells, weak stability under physiological conditions, and endonuclease degradation. Herein, we demonstrate an effective approach to facilitate fast transfection of DNA nanostructures and enhance their stability by encapsulating DNA origami with a biocompatible cationic protein (cHSA) via electrostatic interaction. The coated DNA origami is found to be stable under physiological conditions. Moreover, the cHSA coating could significantly improve the cellular transfection efficiency of DNA origami, which is essential for biological applications.
pdf:docinfo:subject: DNA nanostructures, owing to their controllable and adaptable nature, have been considered as highly attractive nanoplatforms for biomedical applications in recent years. However, their use in the biological environment has been restricted by low cellular transfection efficiency in mammalian cells, weak stability under physiological conditions, and endonuclease degradation. Herein, we demonstrate an effective approach to facilitate fast transfection of DNA nanostructures and enhance their stability by encapsulating DNA origami with a biocompatible cationic protein (cHSA) via electrostatic interaction. The coated DNA origami is found to be stable under physiological conditions. Moreover, the cHSA coating could significantly improve the cellular transfection efficiency of DNA origami, which is essential for biological applications.
pdf:docinfo:creator: Xuemei Xu, Shiqi Fang, Yuan Zhuang, Shanshan Wu, Qingling Pan, Longjie Li, Xiaohui Wang, Xueqing Sun, Bifeng Liu and Yuzhou Wu
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Creation-Date: 2019-03-21T09:50:39Z
Author: Xuemei Xu, Shiqi Fang, Yuan Zhuang, Shanshan Wu, Qingling Pan, Longjie Li, Xiaohui Wang, Xueqing Sun, Bifeng Liu and Yuzhou Wu
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dc:description: DNA nanostructures, owing to their controllable and adaptable nature, have been considered as highly attractive nanoplatforms for biomedical applications in recent years. However, their use in the biological environment has been restricted by low cellular transfection efficiency in mammalian cells, weak stability under physiological conditions, and endonuclease degradation. Herein, we demonstrate an effective approach to facilitate fast transfection of DNA nanostructures and enhance their stability by encapsulating DNA origami with a biocompatible cationic protein (cHSA) via electrostatic interaction. The coated DNA origami is found to be stable under physiological conditions. Moreover, the cHSA coating could significantly improve the cellular transfection efficiency of DNA origami, which is essential for biological applications.
Keywords: cationic albumin; DNA origami; cellular uptake; stability
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dc:creator: Xuemei Xu, Shiqi Fang, Yuan Zhuang, Shanshan Wu, Qingling Pan, Longjie Li, Xiaohui Wang, Xueqing Sun, Bifeng Liu and Yuzhou Wu
description: DNA nanostructures, owing to their controllable and adaptable nature, have been considered as highly attractive nanoplatforms for biomedical applications in recent years. However, their use in the biological environment has been restricted by low cellular transfection efficiency in mammalian cells, weak stability under physiological conditions, and endonuclease degradation. Herein, we demonstrate an effective approach to facilitate fast transfection of DNA nanostructures and enhance their stability by encapsulating DNA origami with a biocompatible cationic protein (cHSA) via electrostatic interaction. The coated DNA origami is found to be stable under physiological conditions. Moreover, the cHSA coating could significantly improve the cellular transfection efficiency of DNA origami, which is essential for biological applications.
dcterms:created: 2019-03-21T09:50:39Z
Last-Modified: 2019-04-09T10:22:50Z
dcterms:modified: 2019-04-09T10:22:50Z
title: Cationic Albumin Encapsulated DNA Origami for Enhanced Cellular Transfection and Stability
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pdf:docinfo:keywords: cationic albumin; DNA origami; cellular uptake; stability
pdf:docinfo:modified: 2019-04-09T10:22:50Z
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creator: Xuemei Xu, Shiqi Fang, Yuan Zhuang, Shanshan Wu, Qingling Pan, Longjie Li, Xiaohui Wang, Xueqing Sun, Bifeng Liu and Yuzhou Wu
dc:subject: cationic albumin; DNA origami; cellular uptake; stability
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pdf:docinfo:created: 2019-03-21T09:50:39Z