date: 2019-12-04T08:59:15Z pdf:PDFVersion: 1.5 pdf:docinfo:title: Theoretical Analysis of Forced Segmented Temperature Gradients in Liquid Chromatography xmp:CreatorTool: LaTeX with hyperref package access_permission:can_print_degraded: true subject: An equilibrium model is applied to study the effect of forced temperature gradients introduced through heat exchange via specific segments of the wall of a chromatographic column operating with a liquid mobile phase. For illustration of the principle, the column is divided into two segments in such a manner that the first segment is kept at a fixed reference temperature, while the temperature of the second segment can be changed stepwise through fixed heating or cooling over the column wall to modulate the migration speeds of the solute concentration profiles. The method of characteristics is used to obtain the solution trajectories analytically. It is demonstrated that appropriate heating or cooling in the second segment can accelerate or decelerate the specific concentration profiles in order to improve certain performance criteria. The results obtained verify that the proposed analysis is well suited to evaluate the application of forced segmented temperature gradients. The suggested gradient procedure provides the potential to reduce the cycle time and, thus, improving the production rate of the chromatographic separation process compared to conventional isothermal (isocratic) operation. dc:format: application/pdf; version=1.5 pdf:docinfo:creator_tool: LaTeX with hyperref package access_permission:fill_in_form: true pdf:encrypted: false dc:title: Theoretical Analysis of Forced Segmented Temperature Gradients in Liquid Chromatography modified: 2019-12-04T08:59:15Z cp:subject: An equilibrium model is applied to study the effect of forced temperature gradients introduced through heat exchange via specific segments of the wall of a chromatographic column operating with a liquid mobile phase. For illustration of the principle, the column is divided into two segments in such a manner that the first segment is kept at a fixed reference temperature, while the temperature of the second segment can be changed stepwise through fixed heating or cooling over the column wall to modulate the migration speeds of the solute concentration profiles. The method of characteristics is used to obtain the solution trajectories analytically. It is demonstrated that appropriate heating or cooling in the second segment can accelerate or decelerate the specific concentration profiles in order to improve certain performance criteria. The results obtained verify that the proposed analysis is well suited to evaluate the application of forced segmented temperature gradients. The suggested gradient procedure provides the potential to reduce the cycle time and, thus, improving the production rate of the chromatographic separation process compared to conventional isothermal (isocratic) operation. pdf:docinfo:subject: An equilibrium model is applied to study the effect of forced temperature gradients introduced through heat exchange via specific segments of the wall of a chromatographic column operating with a liquid mobile phase. For illustration of the principle, the column is divided into two segments in such a manner that the first segment is kept at a fixed reference temperature, while the temperature of the second segment can be changed stepwise through fixed heating or cooling over the column wall to modulate the migration speeds of the solute concentration profiles. The method of characteristics is used to obtain the solution trajectories analytically. It is demonstrated that appropriate heating or cooling in the second segment can accelerate or decelerate the specific concentration profiles in order to improve certain performance criteria. The results obtained verify that the proposed analysis is well suited to evaluate the application of forced segmented temperature gradients. The suggested gradient procedure provides the potential to reduce the cycle time and, thus, improving the production rate of the chromatographic separation process compared to conventional isothermal (isocratic) operation. pdf:docinfo:creator: PTEX.Fullbanner: This is pdfTeX, Version 3.14159265-2.6-1.40.18 (TeX Live 2017/W32TeX) kpathsea version 6.2.3 trapped: False meta:creation-date: 2019-11-12T05:38:08Z created: 2019-11-12T05:38:08Z access_permission:extract_for_accessibility: true Creation-Date: 2019-11-12T05:38:08Z producer: pdfTeX-1.40.18 pdf:docinfo:producer: pdfTeX-1.40.18 pdf:unmappedUnicodeCharsPerPage: 17 dc:description: An equilibrium model is applied to study the effect of forced temperature gradients introduced through heat exchange via specific segments of the wall of a chromatographic column operating with a liquid mobile phase. For illustration of the principle, the column is divided into two segments in such a manner that the first segment is kept at a fixed reference temperature, while the temperature of the second segment can be changed stepwise through fixed heating or cooling over the column wall to modulate the migration speeds of the solute concentration profiles. The method of characteristics is used to obtain the solution trajectories analytically. It is demonstrated that appropriate heating or cooling in the second segment can accelerate or decelerate the specific concentration profiles in order to improve certain performance criteria. The results obtained verify that the proposed analysis is well suited to evaluate the application of forced segmented temperature gradients. The suggested gradient procedure provides the potential to reduce the cycle time and, thus, improving the production rate of the chromatographic separation process compared to conventional isothermal (isocratic) operation. Keywords: liquid chromatography; equilibrium model; temperature gradients; external heating or cooling source; method of characteristics; periodic injection; cycle time; production rate access_permission:modify_annotations: true description: An equilibrium model is applied to study the effect of forced temperature gradients introduced through heat exchange via specific segments of the wall of a chromatographic column operating with a liquid mobile phase. For illustration of the principle, the column is divided into two segments in such a manner that the first segment is kept at a fixed reference temperature, while the temperature of the second segment can be changed stepwise through fixed heating or cooling over the column wall to modulate the migration speeds of the solute concentration profiles. The method of characteristics is used to obtain the solution trajectories analytically. It is demonstrated that appropriate heating or cooling in the second segment can accelerate or decelerate the specific concentration profiles in order to improve certain performance criteria. The results obtained verify that the proposed analysis is well suited to evaluate the application of forced segmented temperature gradients. The suggested gradient procedure provides the potential to reduce the cycle time and, thus, improving the production rate of the chromatographic separation process compared to conventional isothermal (isocratic) operation. dcterms:created: 2019-11-12T05:38:08Z Last-Modified: 2019-12-04T08:59:15Z dcterms:modified: 2019-12-04T08:59:15Z title: Theoretical Analysis of Forced Segmented Temperature Gradients in Liquid Chromatography xmpMM:DocumentID: uuid:538f5b46-97cd-49e9-a18a-223d799ef4dd Last-Save-Date: 2019-12-04T08:59:15Z pdf:docinfo:keywords: liquid chromatography; equilibrium model; temperature gradients; external heating or cooling source; method of characteristics; periodic injection; cycle time; production rate pdf:docinfo:modified: 2019-12-04T08:59:15Z meta:save-date: 2019-12-04T08:59:15Z pdf:docinfo:custom:PTEX.Fullbanner: This is pdfTeX, Version 3.14159265-2.6-1.40.18 (TeX Live 2017/W32TeX) kpathsea version 6.2.3 Content-Type: application/pdf X-Parsed-By: org.apache.tika.parser.DefaultParser dc:subject: liquid chromatography; equilibrium model; temperature gradients; external heating or cooling source; method of characteristics; periodic injection; cycle time; production rate access_permission:assemble_document: true xmpTPg:NPages: 19 pdf:charsPerPage: 2955 access_permission:extract_content: true access_permission:can_print: true pdf:docinfo:trapped: False meta:keyword: liquid chromatography; equilibrium model; temperature gradients; external heating or cooling source; method of characteristics; periodic injection; cycle time; production rate access_permission:can_modify: true pdf:docinfo:created: 2019-11-12T05:38:08Z