Researcher Portfolio
Looso, Mario
Bioinformatics, Max Planck Institute for Heart and Lung Research, Max Planck Society
Researcher Profile
Position: Bioinformatics, Max Planck Institute for Heart and Lung Research, Max Planck Society
Researcher ID: https://pure.mpg.de/cone/persons/resource/persons224384
Publications
(1 - 25 of 71)
: Gupta, S., Bajwa, G. K., El-Sammak, H., Mattonet, K., Guenther, S., Looso, M., Stainier, D. Y. R., & Marin-Juez, R. (2025). The transmembrane glycoprotein Gpnmb is required for the immune and fibrotic responses during zebrafish heart regeneration. DEVELOPMENTAL BIOLOGY, 521, 153-162. doi:10.1016/j.ydbio.2025.02.011. [PubMan] : Xu, Y., Gehlot, R., Capon, S. J., Albu, P. M., Gretz, J., Bloomekatz, J., Mattonet, K., Vucicevic, D., Talyan, S., Kikhi, K., Guenther, S., Looso, M., Firulli, B. A., Sanda, M., Firulli, A. B., Lacadie, S. A., Yelon, D., & Stainier, D. Y. R. (2024). PDGFRA is a conserved HAND2 effector during early cardiac development. NATURE CARDIOVASCULAR RESEARCH, 3(12). doi:10.1038/s44161-024-00574-1. [PubMan] : Xu, Y., Gehlot, R., Capon, S. J., Albu, M., Gretz, J., Bloomekatz, J., Mattonet, K., Vucicevic, D., Talyan, S., Kikhi, K., Guenther, S., Looso, M., Firulli, B. A., Sanda, M., Firulli, A. B., Lacadie, S. A., Yelon, D., & Stainier, D. Y. R. (2024). PDGFRA is a conserved HAND2 effector during early cardiac development. NATURE CARDIOVASCULAR RESEARCH, 3(12). doi:10.1038/s44161-024-00574-1. [PubMan] : Wang, Z.-Y., Mehra, A., Wang, Q.-C., Gupta, S., da Silva, A. R., Juan, T., Guenther, S., Looso, M., Detleffsen, J., Stainier, D. Y. R., & Marin-Juez, R. (2024). flt1 inactivation promotes zebrafish cardiac regeneration by enhancing endothelial activity and limiting the fibrotic response. DEVELOPMENT, 151(23): dev203028. doi:10.1242/dev.203028. [PubMan] : Zhou, L., Pereiro, M. T., Li, Y., Derigs, M., Kuenne, C., Hielscher, T., Huang, W., Kraenzlin, B., Tian, G., Kobayashi, K., Lu, G.-H.-N., Roedl, K., Schmidt, C., Guenther, S., Looso, M., Huber, J., Xu, Y., Wiech, T., Sperhake, J.-P., Wichmann, D., Groene, H.-J., & Worzfeld, T. (2024). Glucocorticoids induce a maladaptive epithelial stress response to aggravate acute kidney injury. SCIENCE TRANSLATIONAL MEDICINE, 16(767): eadk5005. doi:10.1126/scitranslmed.adk5005. [PubMan] : Goumenaki, P., Guenther, S., Kikhi, K., Looso, M., Marin-Juez, R., & Stainier, D. Y. R. (2024). The innate immune regulator MyD88 dampens fibrosis during zebrafish heart regeneration. NATURE CARDIOVASCULAR RESEARCH, 3(9), 1158-1176. doi:10.1038/s44161-024-00538-5. [PubMan] : Alayoubi, Y., Bentsen, M., & Looso, M. (2024). Scanpro is a tool for robust proportion analysis of single-cell resolution data. SCIENTIFIC REPORTS, 14(1): 15581. doi:10.1038/s41598-024-66381-7. [PubMan] : Ribeiro da Silva, A., Gunawan, F., Boezio, G. L. M., Faure, E., Theron, A., Avierinos, J.-F., Lim, S., Shivam, G. J., Ramadass, R., Guenther, S., Looso, M., Zaffran, S., Juan, T., & Stainier, D. Y. R. (2024). egr3 is a mechanosensitive transcription factor gene required for cardiac valve morphogenesis. SCIENCE ADVANCES, 10(20): eadl0633. doi:10.1126/sciadv.adl0633. [PubMan] : Jang, J., Bentsen, M., Kim, Y. J., Kim, E., Garg, V., Cai, C.-L., Looso, M., & Li, D. (2024). Endocardial HDAC3 is required for myocardial trabeculation. NATURE COMMUNICATIONS, 15(1): 4166. doi:10.1038/s41467-024-48362-6. [PubMan] : Cardeira-da-Silva, J., Wang, Q., Sagvekar, P., Mintcheva, J., Latting, S., Guenther, S., Ramadass, R., Yekelchyk, M., Preussner, J., Looso, M., Junker, J. P., & Stainier, D. Y. R. (2024). Antigen presentation plays positive roles in the regenerative response to cardiac injury in zebrafish. NATURE COMMUNICATIONS, 15(1): 3637. doi:10.1038/s41467-024-47430-1. [PubMan] : Schultheis, H., Bentsen, M., Heger, V., & Looso, M. (2024). Uncovering uncharacterized binding of transcription factors from ATAC-seq footprinting data. SCIENTIFIC REPORTS, 14(1): 9275. doi:10.1038/s41598-024-59989-2. [PubMan] : Martin, D., Roedel, F., Hehlgans, S., Looso, M., Ziegler, P. K., Fleischmann, M., Diefenhardt, M., Fries, L., Kalinauskaite, G., Tinhofer, I., Zips, D., Gani, C., Roedel, C., & Fokas, E. (2024). Inflammatory pathways confer resistance to chemoradiotherapy in anal squamous cell carcinoma. NPJ PRECISION ONCOLOGY, 8(1): 93. doi:10.1038/s41698-024-00585-y. [PubMan] : Vega-Sendino, M., Luettmann, F. F., Olbrich, T., Chen, Y., Kuenne, C., Stein, P., Tillo, D., Carey, G. I., Zhong, J., Savy, V., Radonova, L., Lu, T., Saykali, B., Kim, K.-P., Domingo, C. N., Schueler, L., Guenther, S., Bentsen, M., Bosnakovski, D., Schoeler, H., Kyba, M., Maity, T. K., Jenkins, L. M., Looso, M., Williams, C. J., Kim, J., & Ruiz, S. (2024). The homeobox transcription factor DUXBL controls exit from totipotency. NATURE GENETICS, (56), 697-709. doi:10.1038/s41588-024-01692-z. [PubMan] : Laub, V., Nan, E., Elias, L., Donaldson, I. J., Bentsen, M., Rusling, L. A., Schupp, J., Lun, J. H., Plate, K. H., Looso, M., Langer, J. D., Guenther, S., Bobola, N., & Schulte, D. (2024). Integrated multi-omics analysis of PBX1 in mouse adult neural stem- and progenitor cells identifies a transcriptional module that functionally links PBX1 to TCF3/4. NUCLEIC ACIDS RESEARCH. doi:10.1093/nar/gkae864. [PubMan] : Wu, F., Li, X., Looso, M., Liu, H., Ding, D., Guenther, S., Kuenne, C., Liu, S., Weissmann, N., Boettger, T., Atzberger, A., Kolahian, S., Renz, H., Offermanns, S., Gaertner, U., Potente, M., Zhou, Y., Yuan, X., & Braun, T. (2024). Spurious transcription causing innate immune responses is prevented by 5-hydroxymethylcytosine. NATURE GENETICS, 55(1), 100-+. doi:10.1038/s41588-022-01252-3. [PubMan] : Hu, J., Leisegang, M. S., Looso, M., Drekolia, M.-K., Wittig, J., Mettner, J., Karantanou, C., Kyselova, A., Dumbovic, G., Li, X., Li, Y., Guenther, S., John, D., Siragusa, M., Zukunft, S., Oo, J., Wittig, I., Hille, S., Weigert, A., Knapp, S., Brandes, R. P., Muller, O. J., Papapetropoulos, A., Sigala, F., Dobreva, G., Kojonazarov, B., Fleming, I., & Bibli, S.-I. (2023). Disrupted Binding of Cystathionine gamma-Lyase to p53 Promotes Endothelial Senescence. Circulation research. doi:10.1161/CIRCRESAHA.123.323084. [PubMan] : Li, X., Wu, F., Guenther, S., Looso, M., Kuenne, C., Zhang, T., Wiesnet, M., Klatt, S., Zukunft, S., Fleming, I., Poschet, G., Wietelmann, A., Atzberger, A., Potente, M., Yuan, X., & Braun, T. (2023). Inhibition of fatty acid oxidation enables heart regeneration in adult mice. NATURE. doi:10.1038/s41586-023-06585-5. [PubMan] : Khassafi, F., Chelladurai, P., Valasarajan, C., Nayakanti, S. R., Martineau, S., Sommer, N., Yokokawa, T., Boucherat, O., Kamal, A., Kiely, D. G., Swift, A. J., Alabed, S., Omura, J., Breuils-Bonnet, S., Kuenne, C., Potus, F., Guenther, S., Savai, R., Seeger, W., Looso, M., Zaugg, J. B., Tello, K., Provencher, S., Bonnet, S., & Pullamsetti, S. S. (2023). Transcriptional profiling unveils molecular subgroups of adaptive and maladaptive right ventricular remodeling in pulmonary hypertension. NATURE CARDIOVASCULAR RESEARCH, 2(10), 917-+. doi:10.1038/s44161-023-00338-3. [PubMan] : Nayakanti, S. R., Friedrich, A., Sarode, P., Jafari, L., Maroli, G., Boehm, M., Bourgeois, A., Grobs, Y., Khassafi, F., Kuenne, C., Guenther, S., Dabral, S., Wilhelm, J., Weiss, A., Wietelmann, A., Kojonazarov, B., Janssen, W., Looso, M., de Man, F., Provencher, S., Tello, K., Seeger, W., Bonnet, S., Savai, R., Schermuly, R., & Pullamsetti, S. S. (2023). Targeting Wnt-ss-Catenin-FOSL Signaling Ameliorates Right Ventricular Remodeling. CIRCULATION RESEARCH, 132(11), 1468-1485. doi:10.1161/CIRCRESAHA.122.321725. [PubMan] : Boonsanay, B., Mosa, M. H., Looso, M., Weichenhan, D., Ceteci, F., Pudelko, L., Lechel, A., Michel, C. S., Kuenne, C., Farin, H. F., Plass, C., & Greten, F. R. (2023). Loss of SUV420H2-Dependent Chromatin Compaction Drives Right-Sided Colon Cancer Progression. GASTROENTEROLOGY, 164(2), 214-227. doi:10.1053/j.gastro.2022.10.036. [PubMan] : Wu, F., Li, X., Looso, M., Liu, H., Ding, D., Guenther, S., Kuenne, C., Liu, S., Weissmann, N., Boettger, T., Atzberger, A., Kolahian, S., Renz, H., Offermanns, S., Gaertner, U., Potente, M., Zhou, Y., Yuan, X., & Braun, T. (2023). Spurious transcription causing innate immune responses is prevented by 5-hydroxymethylcytosine. NATURE GENETICS, (2023; 55(1)), 100-111. doi:10.1038/s41588-022-01252-3. [PubMan] : Leisegang, M. S., Bains, J. K., Seredinski, S., Oo, J. A., Krause, N. M., Kuo, C.-C., Guenther, S., Cetin, N. S., Warwick, T., Cao, C., Boos, F., Ponce, J. I., Haydar, S., Bednarz, R., Valasarajan, C., Fuhrmann, D. C., Preussner, J., Looso, M., Pullamsetti, S. S., Schulz, M. H., Jonker, H. R. A., Richter, C., Rezende, F., Gilsbach, R., Pflueger-Mueller, B., Wittig, I., Grummt, I., Ribarska, T., Costa, I. G., Schwalbe, H., & Brandes, R. P. (2022). HIF1 alpha-AS1 is a DNA:DNA:RNA triplex-forming lncRNA interacting with the HUSH complex. NATURE COMMUNICATIONS, 13(1): 6563. doi:10.1038/s41467-022-34252-2. [PubMan] : Drekolia, M.-K., Talyan, S., Emidio, R. C., Boon, R. A., Guenther, S., Looso, M., Dumbovic, G., & Bibli, S.-I. (2022). Unravelling the impact of aging on the human endothelial lncRNA transcriptome. FRONTIERS IN GENETICS, 13: 1035380. doi:10.3389/fgene.2022.1035380. [PubMan] : Kuhnert, S., Mansouri, S., Rieger, M. A., Savai, R., Avci, E., Diaz-Pina, G., Padmasekar, M., Looso, M., Hadzic, S., Acker, T., Klatt, S., Wilhelm, J., Fleming, I., Sommer, N., Weissmann, N., Vogelmeier, C., Bals, R., Zeiher, A., Dimmeler, S., Seeger, W., & Pullamsetti, S. S. (2022). Association of Clonal Hematopoiesis of Indeterminate Potential with Inflammatory Gene Expression in Patients with COPD. CELLS, 11(13): 2121. doi:10.3390/cells11132121. [PubMan] : Ustjanzew, A., Preussner, J., Bentsen, M., Kuenne, C., & Looso, M. (2022). i2dash: Creation of Flexible, Interactive, and Web-based Dashboards for Visualization of Omics Data. GENOMICS PROTEOMICS & BIOINFORMATICS, 20(3), 568-577. doi:10.1016/j.gpb.2021.01.007. [PubMan]