Researcher Portfolio
Dr. Zarzycki, Jan
Cellular Operating Systems, Department of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, Max Planck Society, Understanding and Building Metabolism, Department of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, Max Planck Society
Researcher Profile
Position: Postdoc (Understanding and Building Metabolism, Department of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, Max Planck Society)
Position: Staff Scientist (Cellular Operating Systems, Department of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, Max Planck Society)
Researcher ID: https://pure.mpg.de/cone/persons/resource/persons254859
Publications
(1 - 25 of 31)
: Schulz, L., Zarzycki, J., Steinchen, W., Hochberg, G. K. A., & Erb, T. J. (2025). Layered entrenchment maintains essentiality in the evolution of Form I Rubisco complexes. The EMBO Journal, 44, 269-280. doi:10.1038/s44318-024-00311-1. [PubMan] : Lago-Maciel, A., Soares, J. C., Zarzycki, J., Buchanan, C. J., Reif-Trauttmansdorff, T., Schmidt, F. V., Lometto, S., Paczia, N., Schuller, J. M., Hansen, D. F., Heller, G. T., Prinz, S., Hochberg, G. K. A., Pierik, A. J., & Rebelein, J. G. (2024). Methylthio-alkane reductases use nitrogenase metalloclusters for carbon-sulfur bond cleavage. bioRxiv: the preprint server for biology, 2024.10.19.619033. doi:10.1101/2024.10.19.619033. [PubMan] : He, H., Gómez-Coronado, P. A., Zarzycki, J., Barthel, S., Kahnt, J., Claus, P., Klein, M., Klose, M., de Crécy-Lagard, V., Schindler, D., Paczia, N., Glatter, T., & Erb, T. J. (2024). Adaptive laboratory evolution recruits the promiscuity of succinate semialdehyde dehydrogenase to repair different metabolic deficiencies. Nature Communications, 15(1): 8898. doi:10.1038/s41467-024-53156-x. [PubMan] : Küffner, A. M., Pommerenke, B., Kley, L., Ng, J. Z. Y., Prinz, S., Tinzl-Zechner, M., Claus, P., Paczia, N., Zarzycki, J., Hochberg, G. K. A., & Erb, T. J. (2024). Bottom-up reconstruction of minimal pyrenoids provides insights into the evolution and mechanisms of carbon concentration by EPYC1 proteins. bioRxiv: the preprint server for biology, 2024.06.28.601168. [PubMan] : Schulz, L., Zarzycki, J., Steinchen, W., Hochberg, G. K. A., & Erb, T. J. (2024). Layered entrenchment maintains essentiality in protein-protein interactions. bioRxiv: the preprint server for biology, 2024.01.18.576253. [PubMan] : Schmidt, F. V., Schulz, L., Zarzycki, J., Prinz, S., Oehlmann, N. N., Erb, T. J., & Rebelein, J. G. (2024). Structural insights into the iron nitrogenase complex. Nature Structural & Molecular Biology, 31(1), 150-158. doi:10.1038/s41594-023-01124-2. [PubMan] : Nattermann, M., Wenk, S., Pfister, P., He, H., Lee, S., Szymanski, W., Guntermann, N., Zhu, F., Nickel, L., Wallner, C., Zarzycki, J., Paczia, N., Gaißert, N., Franciò, G., Leitner, W., Gonzalez, R., & Erb, T. J. (2023). Engineering a new-to-nature cascade for phosphate-dependent formate to formaldehyde conversion in vitro and in vivo. Nature Communications, 14(1): 2682. doi:10.1038/s41467-023-38072-w. [PubMan] : Marchal, D. G., Schulz, L., Schuster, I., Ivanovska, J., Paczia, N., Prinz, S., Zarzycki, J., & Erb, T. J. (2023). Machine learning-supported enzyme engineering toward improved CO2-fixation of Glycolyl-CoA carboxylase. ACS Synthetic Biology, 12(12), 3521-3530. doi:10.1021/acssynbio.3c00403. [PubMan] : McLean, R., Schwander, T., Diehl, C., Cortina, N. S., Paczia, N., Zarzycki, J., & Erb, T. J. (2023). Exploring alternative pathways for the in vitro establishment of the HOPAC cycle for synthetic CO2 fixation. Science Advances, 9(24): eadh4299. doi:10.1126/sciadv.adh4299. [PubMan] : Kremer, K., Meier, D., Theis, L., Miller, S., Rost-Nasshan, A., Naing, Y. T., Zarzycki, J., Paczia, N., Serrania, J., Blumenkamp, P., Goesmann, A., Becker, A., Thanbichler, M., Hochberg, G. K. A., Carter, M. S., & Erb, T. J. (2023). Functional degeneracy in Paracoccus denitrificans Pd1222 is coordinated via RamB, which links expression of the Glyoxylate cycle to activity of the Ethylmalonyl-CoA pathway. Applied and Environmental Microbiology, 89(7): e0023823. doi:10.1128/aem.00238-23. [PubMan] : Pfister, P., Zarzycki, J., & Erb, T. J. (2023). Structural basis for a cork-up mechanism of the intra-molecular Mesaconyl-CoA transferase. Biochemistry, 62(1), 75-84. doi:10.1021/acs.biochem.2c00532. [PubMan] : Schmidt, F. V., Schulz, L., Zarzycki, J., Oehlmann, N. N., Prinz, S., Erb, T. J., & Rebelein, J. G. (2023). Structural insights into the iron nitrogenase complex. bioRxiv: the preprint server for biology, 2023.05.02.539077. [PubMan] : Schulz, L., Guo, Z., Zarzycki, J., Steinchen, W., Schuller, J. M., Heimerl, T., Prinz, S., Mueller-Cajar, O., Erb, T. J., & Hochberg, G. K. A. (2022). Evolution of increased complexity and specificity at the dawn of form I Rubiscos. Science, 378(6616), 155-160. doi:10.1126/science.abq1416. [PubMan] : Nattermann, M., Burgener, S., Pfister, P., Chou, A., Schulz, L., Lee, S. H., Paczia, N., Zarzycki, J., Gonzalez, R., & Erb, T. J. (2021). Engineering a highly efficient carboligase for synthetic one-carbon metabolism. ACS Catalysis, 11(9), 5396-5404. doi:10.1021/acscatal.1c01237. [PubMan] : Schada von Borzyskowski, L., Erb, T. J., & Zarzycki, J.(2021). Method of producing autotrophic organisms with altered photorespiration and improved CO2 fixation. [PubMan] : Scheffen, M., Marchal, D. G., Beneyton, T., Schuller, S., Klose, M., Diehl, C., Lehmann, J., Pfister, P., Carillo, M., He, H., Aslan, S., Cortina, N. S., Claus, P., Bollschweiler, D., Baret, J.-C., Schuller, J., Zarzycki, J., Bar-Even, A., & Erb, T. J. (2021). A new-to-nature carboxylation module to improve natural and synthetic CO2 fixation. Nature Catalysis, 4, 105-115. doi:10.1038/s41929-020-00557-y. [PubMan] : Erb, T. J., Zarzycki, J., & Scheffen, M. (2021). 5 Synthetic enzymes and pathways for improved carbon capture and conversion. In R. Matthias (Ed. ), Photosynthesis: Biotechnological Applications with Microalgae (pp. 129-146). De Gruyter. [PubMan] : Richter, A. A., Kobus, S., Czech, L., Hoeppner, A., Zarzycki, J., Erb, T. J., Lauterbach, L., Dickschat, J. S., Bremer, E., & Smits, S. H. J. (2020). The architecture of the diaminobutyrate acetyltransferase active site provides mechanistic insight into the biosynthesis of the chemical chaperone ectoine. JOURNAL OF BIOLOGICAL CHEMISTRY, 295(9), 2822-2838. doi:10.1074/jbc.RA119.011277. [PubMan] : Schada v. Borzyskowsi, L., Severi, F., Krueger, K., Hermann, L., Gilardet, A., Sippel, F., Pommerenke, B., Claus, P., Cortina, N. S., Glatter, T., Zauner, S., Zarzycki, J., Fuchs, B. M., Bremer, E., Maier, U. G., Amann I, R., & Erb, T. J. (2019). Marine Proteobacteria metabolize glycolate via the β-hydroxyaspartate cycle. NATURE, 575(7783), 500-+. doi:10.1038/s41586-019-1748-4. [PubMan] : Moog, D., Schmitt, J., Senger, J., Zarzycki, J., Rexer, K.-H., Linne, U., Erb, T. J., & Maier, U. G. (2019). Using a marine microalga as a chassis for polyethylene terephthalate (PET) degradation. MICROBIAL CELL FACTORIES, 18(1): 171. doi:10.1186/s12934-019-1220-z. [PubMan] : Stoffel, G. M. M., Saez, D. A., DeMirci, H., Voegeli, B., Rao, Y., Zarzycki, J., Yoshikuni, Y., Wakatsuki, S., Vohringer-Martinez, E., & Erb, T. J. (2019). Four amino acids define the CO2 binding pocket of enoyl-CoA carboxylases/reductases. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 116(28), 13964-13969. doi:10.1073/pnas.1901471116. [PubMan] : Richer, A. A., Kobus, S., Czech, L., Höppner, A., Zarzycki, J., Erb, T. J., Lauterbach, L., Dickschat, J. S., Bremer, E., & Smits, S. H. J. (2019). Making the stress-protectant ectoine: Structural and biochemical insights into the acetyltransferase EctA. Studia Universitatis Babes-Bolyai, Biologia, 648(1), 110-110. [PubMan] : Seah, B. K. B., Antony, C. P., Huettel, B., Zarzycki, J., Schada v. Borzyskowsi, L., Erb, T. J., Kouris, A., Kleiner, M., Liebeke, M., Dubilier, N., & Gruber-Vodicka, H. R. (2019). Sulfur-oxidizing symbionts without canonical genes for autotrophic CO2 fixation. bioRxiv: the preprint server for biology, 540435, 540435. [PubMan] : Trudeau, D., Edlich-Muth, C., Zarzycki, J., Scheffen, M., Goldsmith, M., Khersonsky, O., Avizemer, Z., Fleishman, S., Cotton, C., Erb, T. J., Tawfik, D., & Bar-Even, A. (2018). Design and in vitro realization of carbon-conserving photorespiration. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 115(49), E11455-E11464. doi:10.1073/pnas.1812605115. [PubMan] : Berhardsgrütter, I., Vögeli, B., Wagner, T., Peter, D., Cortina, N. S., Kahnt, J., Bange, G., Engilberge, S., Girard, E., Riobe, F., Maury, O., Shima, S., Zarzycki, J., & Erb, T. J. (2018). The multicatalytic compartment of propionyl-CoA synthase sequesters a toxic metabolite. NATURE CHEMICAL BIOLOGY, 14(12), 1127. doi:10.1038/s41589-018-0153-x. [PubMan]