Researcher Portfolio

 
   

Alpi, Arno

Former Research Groups, Max Planck Institute of Biochemistry, Max Planck Society, Schulman, Brenda / Molecular Machines and Signaling, Max Planck Institute of Biochemistry, Max Planck Society  

 

Researcher Profile

 
Position: Schulman, Brenda / Molecular Machines and Signaling, Max Planck Institute of Biochemistry, Max Planck Society
Position: Former Research Groups, Max Planck Institute of Biochemistry, Max Planck Society
Researcher ID: https://pure.mpg.de/cone/persons/resource/persons77672

External references

 

Publications

 
 
 : Gottemukkala, K. V., Chrustowicz, J., Sherpa, D., Sepic, S., Tung Vu, D., Karayel, O., Papadopoulou, E. C., Gross, A., Schorpp, K., von Gronau, S., Hadian, K., Murray, P. J., Mann, M., Schulman, B. A., & Alpi, A. F. (2024). Non-canonical substrate recognition by the human WDR26-CTLH E3 ligase regulates prodrug metabolism. Molecular Cell, 84(10), 1948-1963.e11. doi:10.1016/j.molcel.2024.04.014. [PubMan] : Gross, A., Müller, J., Chrustowicz, J., Strasser, A., Gottemukkala, K. V., Sherpa, D., Schulman, B. A., Murray, P. J., & Alpi, A. F. (2024). Skraban-Deardorff intellectual disability syndrome-associated mutations in WDR26 impair CTLH E3 complex assembly. FEBS Letters, 598(9), 978-994. doi:10.1002/1873-3468.14866. [PubMan] : Chrustowicz, J., Sherpa, D., Li, J., Langlois, C. R., Papadopoulou, E. C., Tung Vu, D., Hehl, L. A., Karayel, Ö., Beier, V., Gronau, S. v., Müller, J., Prabu, J. R., Mann, M., Kleiger, G., Alpi, A. F., & Schulman, B. A. (2024). Multisite phosphorylation dictates selective E2-E3 pairing as revealed by Ubc8/UBE2H-GID/CTLH assemblies. Molecular Cell, 84(2), 293-308. doi:10.1016/j.molcel.2023.11.027. [PubMan] : Purser, N., Tripathi-Giesgen, I., Li, J., Scott, D. C., Horn-Ghetko, D., Baek, K., Schulman, B. A., Alpi, A. F., & Kleiger, G. (2023). Catalysis of non-canonical protein ubiquitylation by the ARIH1 ubiquitin ligase. Biochemical Journal, 480(22), 1817-1831. doi:10.1042/BCJ20230373. [PubMan] : Sherpa, D., Mueller, J., Karayel, Ö., Xu, P., Yao, Y., Chrustowicz, J., Gottemukkala, K. V., Baumann, C. A., Gross, A., Czarnecki, O., Zhang, W., Gu, J., Nilvebrant, J., Sidhu, S. S., Murray, P. J., Mann, M., Weiss, M. J., Schulman, B. A., & Alpi, A. F. (2022). Modular UBE2H-CTLH E2-E3 complexes regulate erythroid maturation. eLife, 11: e77937. doi:10.7554/eLife.77937. [PubMan] : Tripathi-Giesgen, I., Behrends, C., & Alpi, A. F. (2021). The ubiquitin ligation machinery in the defense against bacterial pathogens. EMBO Reports, 22(11): e52864. doi:10.15252/embr.202152864. [PubMan] : Sherpa, D., Chrustowicz, J., Qiao, S., Langlois, C. R., Hehl, L. A., Gottemukkala, K. V., Hansen, F. M., Karayel, O., von Gronau, S., Prabu, J. R., Mann, M., Alpi, A. F., & Schulman, B. A. (2021). GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme. Molecular Cell, 81(11), 2445-2459.e13. doi:10.1016/j.molcel.2021.03.025. [PubMan] : Kostrhon, S., Prabu, J. R., Baek, K., Horn-Ghetko, D., Gronau, S. v., Klügel, M., Basquin, J., Alpi, A. F., & Schulman, B. A. (2021). CUL5-ARIH2 E3-E3 ubiquitin ligase structure reveals cullin-specific NEDD8 activation. Nature Chemical Biology, 17(10), 1075-1083. doi:10.1038/s41589-021-00858-8. [PubMan] : Xu, P., Scott, D. C., Xu, B., Yao, Y., Feng, R., Cheng, L., Mayberry, K., Wang, Y.-D., Bi, W., Palmer, L. E., King, M. T., Wang, H., Li, Y., Fan, Y., Alpi, A. F., Li, C., Peng, J., Papizan, J., Pruett-Miller, S. M., Spallek, R., Bassermann, F., Cheng, Y., Schulman, B., & Weiss, M. J. (2021). FBXO11-mediated proteolysis of BAHD1 relieves PRC2-dependent transcriptional repression in erythropoiesis. Blood, 137, 155-167. doi:10.1182/blood.2020007809. [PubMan] : Karayel, Ö., Xu, P., Bludau, I., Velan Bhoopalan, S., Yao, Y., Ana Rita, F., Santos, A., Schulman, B. A., Alpi, A. F., Weiss, M., & Mann, M. (2020). Integrative proteomics reveals principles of dynamic phosphosignaling networks in human erythropoiesis. Molecular Systems Biology, 16(12): e9813. doi:10.15252/msb.20209813. [PubMan] : Qiao, S., Langlois, C. R., Chrustowicz, J., Sherpa, D., Karayel, O., Hansen, F. M., Beier, V., von Gronau, S., Bollschweiler, D., Schäfer, T., Alpi, A. F., Mann, M., Prabu, J. R., & Schulman, B. (2020). Interconversion between Anticipatory and Active GID E3 Ubiquitin Ligase Conformations via Metabolically Driven Substrate Receptor Assembly. MOLECULAR CELL, 77(1), 150-163.e9. doi:10.1016/j.molcel.2019.10.009. [PubMan] : Huttenhain, R., Xu, J., Burton, L. A., Gordon, D. E., Hultquist, J. F., Johnson, J. R., Satkamp, L., Hiatt, J., Rhee, D. Y., Baek, K., Crosby, D. C., Frankel, A. D., Marson, A., Harper, J. W., Alpi, A. F., Schulman, B. A., Gross, J. D., & Krogan, N. J. (2019). ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection. Cell Host & Microbe, 26(1), 86-99.e7. doi:10.1016/j.chom.2019.05.008. [PubMan] : Kelsall, I. R., Kristariyanto, Y. A., Knebel, A., Wood, N. T., Kulathu, Y., & Alpi, A. F. (2019). Coupled monoubiquitylation of the co-E3 ligase DCNL1 by Ariadne-RBR E3 ubiquitin ligases promotes cullin-RING ligase complex remodeling. Journal of Biological Chemistry, 294(8), 2651-2664. doi:10.1074/jbc.RA118.005861. [PubMan] : Xu, P., Scott, D. C., Tang, X., Yao, Y., Wang, Y.-D., Bi, W., Palmer, L. E., Feng, R., Alpi, A. F., Li, C., Cheng, Y., Schulman, B. A., & Weiss, M. J. (2018). FBXO11 Activates Erythroid Gene Transcription By Degrading Heterochromatin-Associated Protein BAHD1. Blood, 132(Suppl. 1), 529-529. [PubMan] : Alpi, A. F., & Echalier, A. (2017). ZOMES: the intriguing interplay of PCI complexes and the ubiquitin in protein homeostasis. Cell Death and Disease, 8: e3021. doi:10.1038/cddis.2017.413. [PubMan] : Scott, D. C., Hammill, J. T., Min, J., Rhee, D. Y., Connelly, M., Sviderskiy, V. O., Bhasin, D., Chen, Y., Ong, S.-S., Chai, S. C., Goktug, A. N., Huang, G., Monda, J. K., Low, J., Kim, H. S., Paulo, J. A., Cannon, J. R., Shelat, A. A., Chen, T., Kelsall, I. R., Alpi, A. F., Pagala, V., Wang, X., Peng, J., Singh, B., Harper, J. W., Schulman, B. A., & Guy, R. K. (2017). Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase. Nature Chemical Biology, 13(8), 850-857. doi:10.1038/nchembio.2386. [PubMan] : Alpi, A. (2004). DNA damage responses in C.elegans. PhD Thesis, Ludwig-Maximilians-Universität, München. [PubMan] : Wicky, C., Alpi, A., Passannante, M., Rose, A., Gartner, A., & Muller, F. (2004). Multiple genetic pathways involving the Caenorhabditis elegans Bloom's syndrome genes him-6, rad-5.1, and top-3 are needed to maintain genome stability in the germ line. Molecular and Cellular Biology, 24(11), 5016-5027. [PubMan] : Schumacher, B., Alpi, A., & Gartner, A. (2003). Cell cycle: Check for asynchrony. Current Biology, 13(14), R560-R562. [PubMan] : Schumacher, B., Alpi, A., Wittenburg, N., Boulton, S., Hofmann, K., Saham, S., Vidal, M., Conradt, B., & Gartner, A. (2003). The roads to death, DNA damage induced apoptosis in the C. elegans germline. European Journal of Cell Biology, 82(Suppl. Suppl. 53), 56-56. [PubMan] : Alpi, A., Pasierbek, P., Gartner, A., & Loidl, J. (2003). Genetic and cytological characterization of the recombination protein RAD-51 in Caenorhabditis elegans. Chromosoma, 112(1), 6-16. [PubMan] : Ahmed, S., Alpi, A., Hengartner, M. O., & Gartner, A. (2001). C-elegans RAD-5/CLK-2 defines a new DNA damage checkpoint protein. Current Biology, 11(24), 1934-1944. [PubMan]