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  A steroid recognition site is functionally coupled to an expressed GABA(A)-benzodiazepine receptor

Lan, N. C., Chen, J.-S., Belleli, D., Pritchett, D. B., Seeburg, P. H., & Gee, K. (1990). A steroid recognition site is functionally coupled to an expressed GABA(A)-benzodiazepine receptor. European Journal of Pharmacology, 88(6), 403-406. doi:10.1016/0922-4106(90)90201-8.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0000-7D8F-4 Version Permalink: https://hdl.handle.net/21.11116/0000-0000-7D90-1
Genre: Journal Article

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EuroJPharmacolMolPharmacolSection_188_1990_403.pdf (Any fulltext), 242KB
 
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EuroJPharmacolMolPharmacolSection_188_1990_403.pdf
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 Creators:
Lan, Nancy C., Author
Chen, Jie-Sheng, Author
Belleli, Delia, Author
Pritchett, Dolan B., Author
Seeburg, Peter H.1, Author           
Gee, KelvinW., Author
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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Free keywords: Pregnane steroids; GABA (α-aminobutyric acid); Benzodiazepine receptors; Receptor gene
 Abstract: Pregnane steroids, particularly 3 alpha-hydroxylated metabolites of progesterone, are known to have rapid and profound effects on brain excitability. Recent evidence suggests that the gamma-aminobutyric acid (GABA(A))-benzodiazepine receptor-Cl- ionophore complex may mediate these actions. The data further suggest that these steroids modulate the complex through a novel site independent of other known sites on the complex. The hypothesis that this site is on the GABA(A)-benzodiazepine receptor-Cl- ionophore complex is tested in the present study by determining its presence on transiently expressed GABAA-benzodiazepine receptors.

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Language(s): eng - English
 Dates: 1990-02-131990-02-192003-02-241990-06-12
 Publication Status: Issued
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/0922-4106(90)90201-8
URI: https://www.ncbi.nlm.nih.gov/pubmed/2164942
 Degree: -

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Title: European Journal of Pharmacology
  Other : European Journal of Pharmacology
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 88 (6) Sequence Number: - Start / End Page: 403 - 406 Identifier: ISSN: 0014-2999
CoNE: https://pure.mpg.de/cone/journals/resource/954925398488