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We report on the first observation of inward rotating spiral waves (antispirals) in a biochemical reaction-diffusion
system. Experiments are performed with extracts from yeast cells in an open spatial reactor. By increasing the protein concentration
of the extract we observe a transition from outward to inward propagating waves of glycolytic activity. Numerical
simulations with an allosteric model for the phosphofructokinase can reproduce these inward propagating waves over a wide
range of parameters if the octameric structure of yeast phosphofructokinase is taken into account.
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