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Schlagwörter:
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Zusammenfassung:
In absence and other generalized seizure disorders, an abnormal electrical activity termed as spike-wave discharges (SWD) is observed by EEG. fMRI
during SWD in humans and animal absence epilepsy models show both increases and decreases in BOLD signals. Here we show regional BOLD
increases/decreases during SWD accompanied by CBV increases/decreases in nearly the same areas for anesthetized WAG/Rij rats. Further work will be
needed to determine if regions of BOLD decreases during SWD represent vascular steal, a primary neuronal mechanism, or a defect in neurovascular
coupling. These findings will be important for the interpretation of various fMRI signals in human absence epilepsy.