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  Observing the hyaluronan component of the extracellular matrix in the brain with quantitative MRI

Metere, R., Jäger, C., Morawski, M., & Möller, H. E. (2018). Observing the hyaluronan component of the extracellular matrix in the brain with quantitative MRI. Poster presented at Joint Annual Meeting ISMRM-ESMRMB 2018, Paris, France.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0004-C420-A Version Permalink: https://hdl.handle.net/21.11116/0000-0004-C421-9
Genre: Poster

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 Creators:
Metere, Riccardo1, Author           
Jäger, Carsten2, Author           
Morawski, Markus3, Author           
Möller, Harald E.1, Author           
Affiliations:
1Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
2Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
3External Organizations, ou_persistent22              

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 Abstract: The tissue composition of the brain can be related to different contrast sources in quantitative MRI. Notably, T1 and T2* strongly correlate with myelin and iron. However, other components may play a role in contrast generation. In particular, the hyaluronan component of the extracellular matrix has been recently proposed as a possible important contributor to MRI contrast. Here, we quantify the bulk contribution of hyaluronan to quantitative relaxation maps. This is obtained by characterizing the evolution of the relevant MRI parameters over time during the enzymatic digestion of the hyaluronan.

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 Dates: 2018-06-19
 Publication Status: Not specified
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Title: Joint Annual Meeting ISMRM-ESMRMB 2018
Place of Event: Paris, France
Start-/End Date: 2018-06-16 - 2018-06-21

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Title: Proceedings of the International Society for Magnetic Resonance in Medicine (2018)
Source Genre: Proceedings
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Pages: - Volume / Issue: - Sequence Number: 2087 Start / End Page: - Identifier: -