Highly enantioselective synthesis of 1,2-amino alcohol derivatives via 
proline-catalyzed Mannich reaction

Pojarliev, P.; Biller, WT; Martin, Heinz; List, Benjamin

doi:10.1055/s-2003-41491

Item

ITEM ACTIONSEXPORT

DownloadE-Mail

Please note that a newer version of this item is available:
https://pure.mpg.de/pubman/item/item_2036330_4

DetailsSummary

Highly enantioselective synthesis of 1,2-amino alcohol derivatives via proline-catalyzed Mannich reaction

Pojarliev, P., Biller, W., Martin, H., & List, B. (2003). Highly enantioselective synthesis of 1,2-amino alcohol derivatives via proline-catalyzed Mannich reaction. Synlett, 12, 1903-1905. doi:10.1055/s-2003-41491.

Item is Released

show all hide all

Basic

show hide

Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0019-D5FC-9 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0019-D5FD-7

Genre: Journal Article

Files

show Files

Locators

show

Creators

show

hide

Creators:
Pojarliev, P.¹, Author
Biller, WT¹, Author
Martin, Heinz², Author
List, Benjamin³, Author

Affiliations:
1Scripps Res Inst, Dept Mol Biol, 10550 N Torrey Pines Rd, La Jolla, CA 92037 USA, ou_persistent22
2Research Group Martin, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445613
3Research Department List, Max-Planck-Institut für Kohlenforschung, Max Planck Society, ou_1445585

Content

show

hide

Free keywords: multicomponent reactions; organocatalysis; oxazolidinones; aminoalcohols

Abstract: Here we report a new catalytic asymmetric synthesis of oxazolidin-2-ones 4 and Cbz-protected 1,2-amino alcohols 5. Our sequence is based on the chemistry of previously unknown 5-acyloxy-oxazolidin-2-ones, which are obtained via proline-catalyzed direct asymmetric three-component Mannich reaction and Baeyer-Villiger oxidation

Details

show

hide

Language(s):

Dates: Date issued: 2003-09-29

Publication Status: Issued

Pages: -

Publishing info: -

Table of Contents: -

Rev. Type: Peer

Identifiers: DOI: 10.1055/s-2003-41491

Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show

hide

Title: Synlett

Other : Synlett

Source Genre: Journal

Creator(s):

Affiliations:

Publ. Info: -

Pages: - Volume / Issue: 12 Sequence Number: - Start / End Page: 1903 - 1905 Identifier: ISSN: 0936-5214
CoNE: https://pure.mpg.de/cone/journals/resource/954925570856