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Free keywords:
TMS; MEP; FEM; GPC; Congruence factor; Modeling; Simulation
Abstract:
Transcranial magnetic stimulation (TMS)
allows for non-invasive electromagnetic
stimulation of the cortex. However, its
exact neurophysiological mechanisms
remain elusive, leading to considerable
variation in observed effects [1].
Depending on stimulation intensity and
target, the stimulation can directly lead
to observable effects, such as motor re-
sponses. Although head modeling allows
for a prediction of the induced electric
field in the head [2], the stimulated
areas may be extended and do not uni-
quely identify the location of the effect
cause.
Here, we present a novel method that
employs biophysical forward modeling
(Fig. 2) and stimulation with variable coil
positions and orientations, in order to
exactly localize the neural populations
that are causally linked to motor evoked
potentials (MEP).
