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Abstract:
The isolation of membranes from defined segments of the nephron and defined regions of renal epithelial cells has provided a new approach to the analysis of renal tubular transport phenomena and hormone action. The new approach makes it possible: (a) to distinguish between the role of the plasma membrane and the role of other cellular components in transcellular transport and hormonal regulation; (b) to localize the transport elements situated in the two opposite poles of the cell, namely, the basal-lateral and the luminal membranes; and (c) to characterize these transport elements in terms of driving forces, molecular properties, and sensitivity to regulatory influences.
