In vitro evolution and analysis of HIV-1 LTR-specific recombinases

Buchholz, Frank; Hauber, Joachim

Local TagsRelease HistoryDetailsSummary

In vitro evolution and analysis of HIV-1 LTR-specific recombinases

Buchholz, F., & Hauber, J. (2011). In vitro evolution and analysis of HIV-1 LTR-specific recombinases. Methods (San Diego, Calif.), 53(1), 102-109.

Item is Released

show all hide all

Basic

show hide

Item Permalink: https://hdl.handle.net/21.11116/0000-0001-0A3A-4 Version Permalink: https://hdl.handle.net/21.11116/0000-0001-0A3B-3

Genre: Journal Article

Files

show Files

Locators

show

Creators

show

hide

Creators:
Buchholz, Frank¹, Author
Hauber, Joachim, Author

Affiliations:
1Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society, ou_2340692

Content

show

hide

Free keywords: -

Abstract: Current antiretroviral therapies would greatly benefit from the concurrent removal of integrated HIV-1 proviral DNA from the patient's cells. In this review, we describe an experimental strategy that allowed the engineering and functional analysis of a HIV-1 LTR-specific recombinase (Tre-recombinase). We furthermore provide protocols that are utilized for the investigation of Tre's antiretroviral activity in infected tissue cultures as well as in infected humanized Rag2(-/-)γc(-/-) mice.

Details

show

hide

Language(s):

Dates: Date issued: 2011

Publication Status: Issued

Pages: -

Publishing info: -

Table of Contents: -

Rev. Type: -

Identifiers: eDoc: 585274
Other: 4708

Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show

hide

Title: Methods (San Diego, Calif.)

Source Genre: Journal

Creator(s):

Affiliations:

Publ. Info: -

Pages: - Volume / Issue: 53 (1) Sequence Number: - Start / End Page: 102 - 109 Identifier: -