New drug for inhibiting aggregation of proteins involved in diseases linked to 
protein aggregation and/or neurodegenerative diseases.

Giese, A.; Bertsch, U.; Kretzschmar, H.; Habeck, M.; Hirschberger, T.; Tavan, P.; Griesinger, C.; Leonov, A.; Ryazanov, S.; Weber, P.

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New drug for inhibiting aggregation of proteins involved in diseases linked to protein aggregation and/or neurodegenerative diseases.

Giese, A., Bertsch, U., Kretzschmar, H., Habeck, M., Hirschberger, T., Tavan, P., et al.(2010). New drug for inhibiting aggregation of proteins involved in diseases linked to protein aggregation and/or neurodegenerative diseases.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-000F-D1F6-C Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0027-D58E-3

Genre: Patent

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Creators:
Giese, A., Author
Bertsch, U., Author
Kretzschmar, H., Author
Habeck, M., Author
Hirschberger, T., Author
Tavan, P., Author
Griesinger, C.¹, Author
Leonov, A.¹, Author
Ryazanov, S.¹, Author
Weber, P., Author

Affiliations:
1Department of NMR-Based Structural Biology, MPI for biophysical chemistry, Max Planck Society, ou_578567

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Abstract: The present invention relates to a compound represented by formula (E). The present invention also relates to a compound represented by the formula (E) for use in the treatment or prevention of diseases linked to protein aggregation and/or neurodegenerative diseases. Moreover, the present invention relates to pharmaceutical and diagnostic compositions comprising the compound of the invention as well as to a kit. Furthermore, the present invention relates to a method of imaging deposits of aggregated protein. A kit for preparing a detectably labelled compound of the present invention is also disclosed. Formula (E) wherein X, Y and L are independently nondirectionally selected from -C(R1)(R2)-, -C(R3)=, -N(R4)-, -N=, -N+(R5)=, -O- and -S-; M and Z are independently nondirectionally selected from formula (I) and formula (II).

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Dates: Submitted: 2009-06-09Published Online: 2010-01-07

Publication Status: Published online

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Identifiers: Patent Nr.: WO/2010/00372
Patent Application Nr.: PCT/EP2009/004144

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