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  Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin

Obermeier, B., Lovato, L., Bruck, W., Forne, I., Imhof, A., Mentele, R., et al. (2011). Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin. Journal of Neuroimmunology, 233(1-2), 245-248.

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Datensatz-Permalink: https://hdl.handle.net/11858/00-001M-0000-0012-1EF0-B Versions-Permalink: https://hdl.handle.net/11858/00-001M-0000-0012-1EF3-5
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Obermeier, B.1, Autor           
Lovato, L.2, Autor
Bruck, W.2, Autor
Forne, I.2, Autor
Imhof, A.2, Autor
Mentele, R.1, Autor           
Lottspeich, F.2, Autor
Turk, K. W.2, Autor
Willis, S. N.2, Autor
Wekerle, H.1, Autor           
Hohlfeld, R.1, Autor           
Hafler, D. A.2, Autor
O'Connor, K. C.2, Autor
Dornmair, K.1, Autor           
Affiliations:
1Department: Neuroimmunology / Wekerle, MPI of Neurobiology, Max Planck Society, ou_1113547              
2[Lovato, Laura; Willis, Simon N.] Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA.; [Lovato, Laura; Willis, Simon N.] Brigham & Womens Hosp, Dept Neurol, Ctr Neurol Dis, Boston, MA 02115 USA.; [Mentele, Reinhard; Lottspeich, Friedrich] Max Planck Inst Biochem, Dept Prot Analyt, D-82152 Martinsried, Germany.; [Brueck, Wolfgang] Univ Med Ctr, Dept Neuropathol, D-37075 Gottingen, Germany.; [Forne, Ignasi; Imhof, Axel] Univ Munich, Lab Prot Analyt, D-80336 Munich, Germany.; [Turk, Katherine W.] Tufts Univ, Sch Med, Boston, MA 02115 USA.; [Hafler, David A.; O'Connor, Kevin C.] Yale Univ, Sch Med, Dept Neurol, New Haven, CT 06510 USA., ou_persistent22              

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Schlagwörter: Multiple sclerosis; B cells; Cerebrospinal fluid; Central nervous system; Oligoclonal bands
 Zusammenfassung: We investigated the overlap shared between the immunoglobulin (Ig) proteome of the cerebrospinal fluid (CSF) and the B cell Ig-transcriptome of CSF and the central nervous system (CNS) tissue of three patients with multiple sclerosis. We determined the IgG-proteomes of CSF by mass spectrometry, and compared them to the IgG-transcriptomes from CSF and brain lesions, which were analyzed by cDNA cloning. Characteristic peptides that were identified in the CSF-proteome could also be detected in the transcriptomes of both, brain lesions and CSF, providing evidence for a strong overlap of the IgG repertoires in brain lesions and in the CSF. (C) 2011 Elsevier B.V. All rights reserved.

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Sprache(n): eng - English
 Datum: 2011-04
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 563248
ISI: 000290070000033
 Art des Abschluß: -

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Titel: Journal of Neuroimmunology
  Alternativer Titel : J. Neuroimmunol.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: AMSTERDAM : ELSEVIER SCIENCE BV
Seiten: - Band / Heft: 233 (1-2) Artikelnummer: - Start- / Endseite: 245 - 248 Identifikator: ISSN: 0165-5728