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  Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin

Obermeier, B., Lovato, L., Bruck, W., Forne, I., Imhof, A., Mentele, R., et al. (2011). Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin. Journal of Neuroimmunology, 233(1-2), 245-248.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0012-1EF0-B Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0012-1EF3-5
Genre: Journal Article

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 Creators:
Obermeier, B.1, Author           
Lovato, L.2, Author
Bruck, W.2, Author
Forne, I.2, Author
Imhof, A.2, Author
Mentele, R.1, Author           
Lottspeich, F.2, Author
Turk, K. W.2, Author
Willis, S. N.2, Author
Wekerle, H.1, Author           
Hohlfeld, R.1, Author           
Hafler, D. A.2, Author
O'Connor, K. C.2, Author
Dornmair, K.1, Author           
Affiliations:
1Department: Neuroimmunology / Wekerle, MPI of Neurobiology, Max Planck Society, ou_1113547              
2[Lovato, Laura; Willis, Simon N.] Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA.; [Lovato, Laura; Willis, Simon N.] Brigham & Womens Hosp, Dept Neurol, Ctr Neurol Dis, Boston, MA 02115 USA.; [Mentele, Reinhard; Lottspeich, Friedrich] Max Planck Inst Biochem, Dept Prot Analyt, D-82152 Martinsried, Germany.; [Brueck, Wolfgang] Univ Med Ctr, Dept Neuropathol, D-37075 Gottingen, Germany.; [Forne, Ignasi; Imhof, Axel] Univ Munich, Lab Prot Analyt, D-80336 Munich, Germany.; [Turk, Katherine W.] Tufts Univ, Sch Med, Boston, MA 02115 USA.; [Hafler, David A.; O'Connor, Kevin C.] Yale Univ, Sch Med, Dept Neurol, New Haven, CT 06510 USA., ou_persistent22              

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Free keywords: Multiple sclerosis; B cells; Cerebrospinal fluid; Central nervous system; Oligoclonal bands
 Abstract: We investigated the overlap shared between the immunoglobulin (Ig) proteome of the cerebrospinal fluid (CSF) and the B cell Ig-transcriptome of CSF and the central nervous system (CNS) tissue of three patients with multiple sclerosis. We determined the IgG-proteomes of CSF by mass spectrometry, and compared them to the IgG-transcriptomes from CSF and brain lesions, which were analyzed by cDNA cloning. Characteristic peptides that were identified in the CSF-proteome could also be detected in the transcriptomes of both, brain lesions and CSF, providing evidence for a strong overlap of the IgG repertoires in brain lesions and in the CSF. (C) 2011 Elsevier B.V. All rights reserved.

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Language(s): eng - English
 Dates: 2011-04
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 563248
ISI: 000290070000033
 Degree: -

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Title: Journal of Neuroimmunology
  Alternative Title : J. Neuroimmunol.
Source Genre: Journal
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Publ. Info: AMSTERDAM : ELSEVIER SCIENCE BV
Pages: - Volume / Issue: 233 (1-2) Sequence Number: - Start / End Page: 245 - 248 Identifier: ISSN: 0165-5728