非表示:
キーワード:
asymmetric catalysis; chiral phosphoric acid; dynamic kinetic resolution; hydrophosphonylation; organocatalysis
要旨:
As mimics of α‐amino acids, α‐amino phosphonates have great promise as antibacterial and anti‐HIV agents as well as protease inhibitors. Racemic α‐branched aldehydes react, in the presence the new chiral phosphoric acid catalyst 1, directly with p‐anisidine (PMPNH2) and a phosphite to furnish β‐branched α‐amino phosphonates highly diastereoselectively and enantioselectively.
