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Free keywords:
atom economy; Doebner-Knoevenagel reaction; malonic acid half esters; (E)-stereoselectivity; α,β-unsaturated esters
Abstract:
Based on a modification of the Doebner–Knoevenagel reaction, a practical and highly efficient synthesis of α,β‐unsaturated esters with excellent regio‐ and stereoselectivity was developed. The reactions are catalyzed by 4‐dimethylaminopyridine in DMF at room temperature or below. Both aliphatic and aromatic aldehydes can readily be used in the process.