English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  How SNARE molecules mediate membrane fusion: Recent insights from molecular simulations.

Risselada, H. J., & Grubmuller, H. (2012). How SNARE molecules mediate membrane fusion: Recent insights from molecular simulations. Current Opinion in Structural Biology, 22(2), 187-196. doi:10.1016/j.sbi.2012.01.007.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-000F-9AF2-4 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0027-CDAF-5
Genre: Journal Article

Files

show Files
hide Files
:
1470174.pdf (Publisher version), 4MB
Name:
1470174.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Creators

show
hide
 Creators:
Risselada, H. J.1, Author              
Grubmuller, H.1, Author              
Affiliations:
1Department of Theoretical and Computational Biophysics, MPI for biophysical chemistry, Max Planck Society, ou_578631              

Content

show
hide
Free keywords: -
 Abstract: SNARE molecules are the core constituents of the protein machinery that facilitate fusion of synaptic vesicles with the presynaptic plasma membrane, resulting in the release of neurotransmitter. On a molecular level, SNARE complexes seem to play a quite versatile and involved role during all stages of fusion. In addition to merely triggering fusion by forcing the opposing membranes into close proximity, SNARE complexes are now seen to also overcome subsequent fusion barriers and to actively guide the fusion reaction up to the expansion of the fusion pore. Here, we review recent advances in the understanding of SNARE-mediated membrane fusion by molecular simulations.

Details

show
hide
Language(s): eng - English
 Dates: 2012-02-232012-04
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.sbi.2012.01.007
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Current Opinion in Structural Biology
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 22 (2) Sequence Number: - Start / End Page: 187 - 196 Identifier: -