English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse
  1. View item / 
  2. Item Summary

Item

ITEM ACTIONSEXPORT
Add to Basket
 Local TagsRelease HistoryDetailsSummary
  Emergence of a new gene from an intergenic region

Heinen, T. J. A. J., Staubach, F., Häming, D., & Tautz, D. (2009). Emergence of a new gene from an intergenic region. Current Biology, 19(18), 1527-1531. doi:10.1016/j.cub.2009.07.049.

Item is

 

show all hide all

Basic

show hide
Item Permalink: https://hdl.handle.net/11858/00-001M-0000-000F-D56D-6 Version Permalink: https://hdl.handle.net/21.11116/0000-000F-75C1-3
Genre: Journal Article

Files

show Files
hide Files
:
Heinen_2009.pdf (Publisher version), 936KB
 
File Permalink:
-
Name:
Heinen_2009.pdf
Description:
-
OA-Status:
Visibility:
Restricted (Max Planck Institute for Evolutionary Biology, MPLM; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-
:
1-s2.0-S0960982209014754-mmc1.pdf (Supplementary material), 2MB
 
File Permalink:
-
Name:
1-s2.0-S0960982209014754-mmc1.pdf
Description:
-
OA-Status:
Visibility:
Restricted (Max Planck Institute for Evolutionary Biology, MPLM; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Heinen, Tobias J. A. J.1, Author           
Staubach, Fabian1, 2, Author           
Häming, Daniela1, Author           
Tautz, Diethard1, Author                 
Affiliations:
1Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445635              
2Guest Group Evolutionary Genomics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445638              

Content

show
hide
Free keywords: -
 Abstract: It is generally assumed that new genes would arise by gene duplication mechanisms, because the signals for regulation and transcript processing would be unlikely to evolve in parallel with a new gene function [1, 2]. We have identified here a transcript in the house mouse (Mus musculus) that has arisen within the past 2.5-3.5 million years in a large intergenic region. The region is present in many mammals, including humans, allowing us to exclude the involvement of gene duplication, transposable elements, or other genome rearrangements, which are typically found for other cases of newly evolved genes [3-8]. The gene has three exons, shows alternative splicing, and is specifically expressed in postmeiotic cells of the testis. The transcript is restricted to species within the genus Musand its emergence correlates with indel mutations in the 5' regulatory region of the transcript. A recent selective sweep is associated with the transcript region in M. m. musculus populations. A knockout in the laboratory strain BL6 results in reduced sperm motility and reduced testis weight. Our results show that cryptic signals for transcript regulation and processing exist in intergenic regions and can become the basis for the evolution of a new functional gene.

Details

show
hide
Language(s): eng - English
 Dates: 2009-06-232009-05-192009-07-082009-09-032009-09-29
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.cub.2009.07.049
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Current Biology
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 19 (18) Sequence Number: - Start / End Page: 1527 - 1531 Identifier: ISSN: 0960-9822 (print)
ISSN: 1879-0445 (online)