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  Asymmetrically modified nucleosomes expand the histone code.

van Rossum, B., Fischle, W., & Selenko, P. (2012). Asymmetrically modified nucleosomes expand the histone code. Nature Structural and Molecular Biology, 19, 1064-1066. doi:10.1038/nsmb.2433.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-2601-6 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0028-1DE7-1
Genre: Journal Article

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http://www.nature.com/nsmb/journal/v19/n11/pdf/nsmb.2433.pdf (Publisher version)
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van Rossum, B., Author
Fischle, W.1, Author           
Selenko, P., Author
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1Research Group of Chromatin Biochemistry, MPI for biophysical chemistry, Max Planck Society, ou_578604              

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 Abstract: According to the 'classical' view, histone modifications are established in an identical fashion on both copies of each of the four core histones, resulting in 'symmetrically' modified nucleosomes. Now, a new study challenges this notion by demonstrating that asymmetric histone modifications exist on individual mononucleosomes in native chromatin and that symmetric and asymmetric modifications signal different biological outcomes, suggesting a radically expanded histone code.

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Language(s): eng - English
 Dates: 2012-11-062012
 Publication Status: Issued
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 Rev. Type: Peer
 Identifiers: DOI: 10.1038/nsmb.2433
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Title: Nature Structural and Molecular Biology
Source Genre: Journal
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Pages: - Volume / Issue: 19 Sequence Number: - Start / End Page: 1064 - 1066 Identifier: -