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Journal Article

Asymmetrically modified nucleosomes expand the histone code.

MPS-Authors
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Fischle,  W.
Research Group of Chromatin Biochemistry, MPI for biophysical chemistry, Max Planck Society;

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1570038.pdf
(Publisher version), 369KB

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Citation

van Rossum, B., Fischle, W., & Selenko, P. (2012). Asymmetrically modified nucleosomes expand the histone code. Nature Structural and Molecular Biology, 19, 1064-1066. doi:10.1038/nsmb.2433.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0010-2601-6
Abstract
According to the 'classical' view, histone modifications are established in an identical fashion on both copies of each of the four core histones, resulting in 'symmetrically' modified nucleosomes. Now, a new study challenges this notion by demonstrating that asymmetric histone modifications exist on individual mononucleosomes in native chromatin and that symmetric and asymmetric modifications signal different biological outcomes, suggesting a radically expanded histone code.