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  Regulatory crosstalk of the metabolic network

Gruning, N. M., Lehrach, H., & Ralser, M. (2010). Regulatory crosstalk of the metabolic network. Trends in Biochemical Sciences, 35(4), 220-227. doi:10.1016/j.tibs.2009.12.001.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7C22-4 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7C23-2
Genre: Journal Article
Alternative Title : Trends Biochem Sci

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Gruning.pdf (Any fulltext), 492KB
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 Creators:
Gruning, N. M.1, Author
Lehrach, H.2, Author              
Ralser, M.2, Author              
Affiliations:
1Max Planck Society, ou_persistent13              
2Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              

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 Abstract: The metabolic network has a modular architecture, is robust to perturbations, and responds to biological stimuli and environmental conditions. Through monitoring by metabolite responsive macromolecules, metabolic pathways interact with the transcriptome and proteome. Whereas pathway interconnecting cofactors and substrates report on the overall state of the network, specialised intermediates measure the activity of individual functional units. Transitions in the network affect many of these regulatory metabolites, facilitating the parallel regulation of the timing and control of diverse biological processes. The metabolic network controls its own balance, chromatin structure and the biosynthesis of molecular cofactors; moreover, metabolic shifts are crucial in the response to oxidative stress and play a regulatory role in cancer.

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Language(s): eng - English
 Dates: 2010-01-07
 Publication Status: Published in print
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 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 554589
DOI: 10.1016/j.tibs.2009.12.001
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Title: Trends in Biochemical Sciences
  Alternative Title : Trends Biochem Sci
Source Genre: Journal
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Pages: - Volume / Issue: 35 (4) Sequence Number: - Start / End Page: 220 - 227 Identifier: ISSN: 0968-0004 (Print)