English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex

Lange, M., Kaynak, B., Forster, U. B., Tönjes, M., Fischer, J. J., Grimm, C., et al. (2008). Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex. Genes and Development, 22(17), 2370-2384. doi:10.1101/gad.471408.

Item is

Basic

show hide
Genre: Journal Article
Alternative Title : Genes Dev

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Lange, Martin1, Author
Kaynak, Bogac1, Author
Forster, Ulrike B., Author
Tönjes, Martje2, Author           
Fischer, Jenny J.2, Author           
Grimm, Christina3, Author           
Schlesinger, Jenny2, Author           
Just, Steffen, Author
Dunkel, Ilona4, Author           
Krueger, Tammo1, Author
Mebus, Siegrun, Author
Lehrach, Hans2, Author           
Lurz, Rudi1, Author
Gobom, Johan2, Author           
Rottbauer, Wolfgang, Author
Abdelilah-Seyfried, Salim, Author
Sperling, Silke2, Author           
Affiliations:
1Max Planck Society, ou_persistent13              
2Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              
3In vitro Ligand Screening (Zoltán Konthur), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479653              
4Computational Epigenetics (Ho-Ryun Chung), Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479658              

Content

show
hide
Free keywords: Heart and skeletal muscle development and function, PHD finger, BAF chromatin remodeling complex, SMARCD3–BAF60 acetylated and methylated histones, Mef2
 Abstract: Chromatin remodeling and histone modifications facilitate access of transcription factors to DNA by promoting the unwinding and destabilization of histone–DNA interactions. We present DPF3, a new epigenetic key factor for heart and muscle development characterized by a double PHD finger. DPF3 is associated with the BAF chromatin remodeling complex and binds methylated and acetylated lysine residues of histone 3 and 4. Thus, DPF3 may represent the first plant homeodomains that bind acetylated lysines, a feature previously only shown for the bromodomain. During development Dpf3 is expressed in the heart and somites of mouse, chicken, and zebrafish. Morpholino knockdown of dpf3 in zebrafish leads to incomplete cardiac looping and severely reduced ventricular contractility, with disassembled muscular fibers caused by transcriptional deregulation of structural and regulatory proteins. Promoter analysis identified Dpf3 as a novel downstream target of Mef2a. Taken together, DPF3 adds a further layer of complexity to the BAF complex by representing a tissue-specific anchor between histone acetylations as well as methylations and chromatin remodeling. Furthermore, this shows that plant homeodomain proteins play a yet unexplored role in recruiting chromatin remodeling complexes to acetylated histones.

Details

show
hide
Language(s): eng - English
 Dates: 2008-09-01
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Genes and Development
  Alternative Title : Genes Dev
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 22 (17) Sequence Number: - Start / End Page: 2370 - 2384 Identifier: ISSN: 0890-9369